0 -> E2F
0 -> E2F
RE -> E2F + PRB
RE -> E2F + PRB
E2F -> 0
E2F + RB -> RE
0 -> miR449
miR449 -> 0
Myc + miR449 -> 0
CycD + miR449 -> 0
CycE + miR449 -> 0
0 -> Myc
Myc -> 0
0 -> CycD
0 -> CycD
CycD -> 0
0 -> CycE
CycE -> 0
0 -> RB
PRB -> RB
RB -> 0
RB -> PRB
RB -> PRB
PRB -> 0
RE -> 0