Rb -> pRb RbE2f -> E2f + pRb pRb -> Rb 0 -> E2f E2f -> 0 RbE2f -> Rb E2f + Rb -> RbE2f RbE2f -> E2f + Rb 0 -> P21 E2f -> Ce + E2f E2f -> Ca + E2f Ce + P21 -> CeP21 CeP21 -> Ce + P21 Ca + P21 -> CaP21 CaP21 -> Ca + P21 CeP21 -> Ce CaP21 -> Ca Ce -> 0 CeP21 -> P21 Ca -> 0 CaP21 -> P21 P21 -> 0 E2f -> E1 + E2f E1 -> 0 C1 + E1 -> E1C1 E1C1 -> C1 + E1 E1C1 -> C1 C1 -> pC1 E1C1 -> E1 + pC1 pC1 -> C1 0 -> aPcna aPcna -> 0 iPcna -> P21 P21 + aPcna -> iPcna iPcna -> P21 + aPcna iPcna -> aPcna aPcna + pRc -> aRc aRc -> aPcna + pRc iPcna + pRc -> iRc iRc -> iPcna + pRc Rc -> pRc pRc -> Rc P21 + aRc -> iRc iRc -> P21 + aRc iRc -> aRc Rc -> 0 pRc -> 0 aRc -> aPcna iRc -> iPcna aRc -> Dna + aRc 0 -> P53 P53 -> 0 0 -> Dam aRc -> Dam + aRc 0 -> Pr Pr -> 0 Dam -> 0