pEGFR -> fEGFR fEGFR -> pEGFR RafPPtase + pRaf1 -> Raf1 + RafPPtase Raf1 + RafPPtase -> RafPPtase + pRaf1 pAkt + pRaf1 -> Raf1 + pAkt Raf1 + pAkt -> pAkt + pRaf1 MEK + pBRaf -> pBRaf + pMEK pBRaf + pMEK -> MEK + pBRaf MEK + pRKIP + pRaf1 -> pMEK + pRKIP + pRaf1 pMEK + pRKIP + pRaf1 -> MEK + pRKIP + pRaf1 PP2A + pMEK -> MEK + PP2A MEK + PP2A -> PP2A + pMEK ERK + pMEK -> pERK + pMEK pERK + pMEK -> ERK + pMEK PP2A + pERK -> ERK + PP2A ERK + PP2A -> PP2A + pERK RKIP + pERK -> pERK + pRKIP pERK + pRKIP -> RKIP + pERK pRKIP -> RKIP RKIP -> pRKIP RKIP -> null null -> RKIP BRaf + pRas -> pBRaf + pRas pBRaf + pRas -> BRaf + pRas BRaf + pRap1 -> pBRaf + pRap1 pBRaf + pRap1 -> BRaf + pRap1 pP90Rsk -> P90Rsk P90Rsk -> pP90Rsk P90Rsk + pERK -> pERK + pP90Rsk pERK + pP90Rsk -> P90Rsk + pERK PI3K + bEGFR -> bEGFR + pPI3K bEGFR + pPI3K -> PI3K + bEGFR PI3K -> pPI3K pPI3K -> PI3K pPI3K -> PI3K PI3K -> pPI3K EGF + fEGFR -> bEGFR bEGFR -> EGF + fEGFR PIP2 + pPI3K -> PIP3 + pPI3K PIP3 + pPI3K -> PIP2 + pPI3K PIP3 + PTEN -> PIP2 + PTEN PIP2 + PTEN -> PIP3 + PTEN Akt + PIP3 -> PIP3 + pAkt PIP3 + pAkt -> Akt + PIP3 pAkt -> Akt Akt -> pAkt C3G + bEGFR -> bEGFR + pC3G bEGFR + pC3G -> C3G + bEGFR pC3G -> C3G C3G -> pC3G Rap1 + pC3G -> pC3G + pRap1 pC3G + pRap1 -> Rap1 + pC3G Rap1Gap + pRap1 -> Rap1 + Rap1Gap Rap1 + Rap1Gap -> Rap1Gap + pRap1 GSK3B -> GSK3B + PKCD GSK3B + PKCD -> GSK3B PKCD -> null null -> PKCD GSK3B + pERK -> pERK + pGSK3B pERK + pGSK3B -> GSK3B + pERK GSK3B + pAkt -> pAkt + pGSK3B pAkt + pGSK3B -> GSK3B + pAkt RKIP -> GSK3B + RKIP GSK3B + RKIP -> RKIP pGSK3B -> GSK3B GSK3B -> pGSK3B Dshi -> Dsha Dsha -> Dshi Dsha -> Dshi Dshi -> Dsha fEGFR -> null null -> fEGFR APCAxinGSK3B + Dsha -> APCAxin + Dsha + GSK3B APCAxin + Dsha + GSK3B -> APCAxinGSK3B + Dsha APCAxin + GSK3B -> APCAxinGSK3B APCAxinGSK3B -> APCAxin + GSK3B APCAxinGSK3B -> pAPCpAxinGSK3B pAPCpAxinGSK3B -> APCAxinGSK3B pAPCpAxinGSK3B -> APCAxinGSK3B APCAxinGSK3B -> pAPCpAxinGSK3B APC + Axin -> APCAxin APCAxin -> APC + Axin Axin -> null null -> Axin BCatenin + TCFBCatenin -> Axin + BCatenin + TCFBCatenin Axin + BCatenin + TCFBCatenin -> BCatenin + TCFBCatenin BCatenin + pAPCpAxinGSK3B -> pAPCpAxinGSK3BBCatenin pAPCpAxinGSK3BBCatenin -> BCatenin + pAPCpAxinGSK3B pAPCpAxinGSK3BBCatenin -> pAPCpAxinGSK3BpBCatenin pAPCpAxinGSK3BpBCatenin -> pAPCpAxinGSK3BBCatenin pAPCpAxinGSK3BpBCatenin -> pAPCpAxinGSK3B + pBCatenin pAPCpAxinGSK3B + pBCatenin -> pAPCpAxinGSK3BpBCatenin APC + BCatenin -> APCBCatenin APCBCatenin -> APC + BCatenin null -> BCatenin BCatenin -> null BCatenin -> null null -> BCatenin BCatenin + TCF -> TCFBCatenin TCFBCatenin -> BCatenin + TCF TCFBCatenin -> TCFBCatenin + X TCFBCatenin + X -> TCFBCatenin bEGFR -> null null -> bEGFR X -> null null -> X pBCatenin -> null null -> pBCatenin PKCD + SOS + bEGFR + pERK -> PKCD + bEGFR + pERK + pSOS PKCD + bEGFR + pERK + pSOS -> PKCD + SOS + bEGFR + pERK pSOS -> SOS SOS -> pSOS pP90Rsk + pSOS -> SOS + pP90Rsk SOS + pP90Rsk -> pP90Rsk + pSOS Ras + pSOS -> pRas + pSOS pRas + pSOS -> Ras + pSOS null -> Ras Ras -> null RasGap + pRas -> Ras + RasGap Ras + RasGap -> RasGap + pRas Raf1 + pRas -> pRaf1 + pRas pRaf1 + pRas -> Raf1 + pRas Raf1 + X -> X + pRaf1 X + pRaf1 -> Raf1 + X