IRS -> aIRS aIRS -> IRS PI3K -> aPI3K aPI3K -> PI3K Akt -> aAkt aAkt -> Akt mTORC1 -> amTORC1 amTORC1 -> mTORC1 S6K -> aS6K aS6K -> S6K IRS -> iIRS RTK -> aRTK aRTK -> RTK RasGDP -> RasGTP RasGTP -> RasGDP Raf -> aRaf aRaf -> Raf MEK -> aMEK aMEK -> MEK ERK -> aERK aERK -> ERK Raf -> iRaf iRaf -> Raf RTK -> iRTK iRTK -> RTK FOXO -> iFOXO iFOXO -> FOXO Akt + AktI -> iAkt iAkt -> Akt + AktI MEK + MEKI -> iMEK iMEK -> MEK + MEKI