Bax + Caspase_I -> Bax + Caspase_A
Beclin_I + Caspase_I -> Beclin_I + Caspase_A
Caspase_I + p38_P -> Caspase_A + p38_P
Caspase_A -> Caspase_I
Bcl2_Beclin + Caspase_A -> Bcl2_Beclin + Caspase_I
Bcl2 + Caspase_A -> Bcl2 + Caspase_I
Beclin + Lys_I -> Beclin + Lys_A
Lys_A -> Lys_I
Source -> Bcl2
Bcl2 -> Sink
Bcl2 + ROS -> ROS + Sink
Bcl2 + Caspase_A -> Caspase_A + Sink
Bax + Bcl2 -> Bax_Bcl2
Bax_Bcl2 -> Bax + Bcl2
Bcl2 + Beclin -> Bcl2_Beclin
Bcl2_Beclin -> Bcl2 + Beclin
Bcl2 + Beclin_I -> Bcl2_Beclin_I
Bcl2_Beclin_I -> Bcl2 + Beclin_I
Beclin -> Beclin_I
Beclin + Caspase_A -> Beclin_I + Caspase_A
Bax_Bcl2 + Beclin -> Bax_Bcl2_Beclin
Bax_Bcl2 + Beclin_I -> Bax_Bcl2_Beclin_I
Bax + Bcl2_Beclin -> Bax_Bcl2_Beclin
Bax + Bcl2_Beclin_I -> Bax_Bcl2_Beclin_I
Bax_Bcl2_Beclin -> Bax + Bcl2_Beclin
Bax_Bcl2_Beclin_I -> Bax + Bcl2_Beclin_I
Bax_Bcl2_Beclin -> Bax_Bcl2 + Beclin
Bax_Bcl2_Beclin_I -> Bax_Bcl2 + Beclin_I
Source -> ROS
ROS -> Sink
NatP + ROS -> DamP + ROS
DamP + Lys_A -> Lys_A
Source -> AGEprod
AGEprod -> AGEprod + RAGE
RAGE -> RAGE + ROS
IkB_NFkB + ROS -> NFkB + ROS
IL1 + IkB_NFkB -> IL1 + NFkB
IkB + NFkB -> IkB_NFkB
RAGE -> Sink
NFkB_P -> NFkB_P + RAGE
NFkB_P -> IL1 + NFkB_P
IL1 -> Sink
NFkB_P -> IkB + NFkB_P
IL1 -> IL1 + proMMP13
MMP13 -> Sink
IL1 -> IL1 + proMMP2
proMMP2 -> MMP2
MMP2 -> Sink
IL1 -> ADAMTS5 + IL1
ADAMTS5 -> Sink
ADAMTS5 + Aggrecan_Collagen2 -> ADAMTS5 + AggFrag + Collagen2
Collagen2 + MMP13 -> ColFrag + MMP13
DamP -> DamP + ROS
Source -> NatP
NFkB_P -> NFkB_P + SOD
SOD -> Sink
ROS + SOD -> SOD
IL1 + p38 -> IL1 + p38_P
ROS + p38 -> ROS + p38_P
p38_P -> p38
NFkB + p38_P -> NFkB_P + p38_P
NFkB_P -> NFkB
p38_P -> ROS + p38_P
Lys_A + ROS -> Lys_I + ROS
Source -> Integrin + IntegrinCount
Integrin -> Sink
Source -> Alk5
Integrin + Tgfb_I -> Integrin + Tgfb_A
MMP2 + Tgfb_I -> MMP2 + Tgfb_A
Tgfb_A -> Tgfb_I
2*Alk5 -> Alk5_dimer
Alk5_dimer -> 2*Alk5
Alk1 + Alk5 -> Alk1_Alk5
Alk1_Alk5 -> Alk1 + Alk5
Alk5_dimer + Tgfb_A -> Tgfb_Alk5_dimer
Tgfb_Alk5_dimer -> Alk5_dimer + Tgfb_A
Smad7 + Tgfb_Alk5_dimer -> Tgfb_Alk5_dimer_Smad7
Tgfb_Alk5_dimer_Smad7 -> Smad7 + Tgfb_Alk5_dimer
Tgfb_Alk5_dimer_Smad7 -> Tgfb_I
Alk1_Alk5 + Tgfb_A -> Tgfb_Alk1_Alk5
Tgfb_Alk1_Alk5 -> Alk1_Alk5 + Tgfb_A
Smad2 + Tgfb_Alk5_dimer -> Smad2_P + Tgfb_Alk5_dimer
Smad2_P + Smad4 -> Smad2_P_Smad4
Smad2_P_Smad4 -> Smad2_P + Smad4
Smad2_P -> Smad2
Smad2_P_Smad4 -> Smad2_P_Smad4 + Smad7
Smad2_P_Smad4 + Sox9 -> Smad2_P_Smad4 + Sox9_A
Sox9_A -> Sox9
Source -> Sox9mRNA
Sox9_A -> Sox9_A + Sox9mRNA
Sox9mRNA -> Sink
Sox9mRNA -> Sox9 + Sox9mRNA
Sox9 -> Sink
Sox9_A -> Col2mRNA + Sox9_A
Smad2_P_Smad4 -> Col2mRNA + Smad2_P_Smad4
Col2mRNA -> Sink
Col2mRNA -> Col2mRNA + Collagen2
Sox9_A -> AcanmRNA + Sox9_A
AcanmRNA -> Sink
AcanmRNA -> AcanmRNA + Aggrecan
Aggrecan + Collagen2 -> Aggrecan_Collagen2
Runx2_A + Smad2_P_Smad4 -> Runx2_I + Smad2_P_Smad4
Alk5 -> Sink
Smad1 + Tgfb_Alk1_Alk5 -> Smad1_P + Tgfb_Alk1_Alk5
Smad1_P -> Smad1
Smad1_P + Smad7 -> Smad1 + Smad7
Smad1_P + Smad4 -> Smad1_P_Smad4
Smad1_P_Smad4 -> Smad1_P + Smad4
Runx2_I + Smad1_P_Smad4 -> Runx2_A + Smad1_P_Smad4
Runx2_A -> Runx2_A + proMMP13
Source -> Alk1
Alk1 -> Sink
proMMP13 -> MMP13
Smad7 + Tgfb_Alk1_Alk5 -> Tgfb_Alk1_Alk5_Smad7
Tgfb_Alk1_Alk5_Smad7 -> Smad7 + Tgfb_Alk1_Alk5
Tgfb_Alk1_Alk5_Smad7 -> Tgfb_I
Smad7 -> Sink