IL1 + IL1R -> IL1_IL1R IL1_IL1R -> IL1 + IL1R IL1 + IL1Ra -> IL1_IL1Ra IL1_IL1Ra -> IL1 + IL1Ra IL1 -> Sink IL1_IL1R + IRAK2 -> IL1_IL1R_IRAK2 IL1_IL1R_IRAK2 -> IL1_IL1R + IRAK2 IL1_IL1R_IRAK2 + TRAF6 -> IL1_IL1R + IRAK2_TRAF6 IRAK2_TRAF6 -> IRAK2 + TRAF6 IRAK2_TRAF6 + JNK -> IRAK2_TRAF6 + JNK_P JNK_P -> JNK DUSP16 + JNK_P -> DUSP16 + JNK JNK_P + cJun -> JNK_P + cJun_P cJun_P -> cJun 2*cJun_P -> cJun_dimer cJun_dimer -> 2*cJun_P cFos_cJun -> cFos_cJun + cJun_mRNA cJun_dimer -> cJun_dimer + cJun_mRNA Source -> cJun_mRNA cJun_mRNA -> Sink cJun_mRNA -> cJun + cJun_mRNA cJun -> Sink IRAK2_TRAF6 + p38 -> IRAK2_TRAF6 + p38_P p38_P -> p38 MKP1 + p38_P -> MKP1 + p38 cFos_cJun -> MMP1_mRNA + cFos_cJun cJun_dimer -> MMP1_mRNA + cJun_dimer MMP1_mRNA -> MMP1_mRNA + proMMP1 MMP1_mRNA -> Sink Matriptase + proMMP1 -> MMP1 + Matriptase MMP3 + proMMP1 -> MMP1 + MMP3 MMP1 -> Sink cFos_cJun -> MMP3_mRNA + cFos_cJun cJun_dimer -> MMP3_mRNA + cJun_dimer MMP3_mRNA -> MMP3_mRNA + proMMP3 MMP3_mRNA -> Sink Matriptase + proMMP3 -> MMP3 + Matriptase MMP3 -> Sink cFos_cJun -> MMP13_mRNA + cFos_cJun cJun_dimer -> MMP13_mRNA + cJun_dimer MMP13_mRNA -> MMP13_mRNA + proMMP13 MMP13_mRNA -> Sink MMP3 + proMMP13 -> MMP13 + MMP3 MMP13 -> Sink TIMP1_mRNA -> TIMP1 + TIMP1_mRNA TIMP1_mRNA -> Sink TIMP1 -> Sink cFos_cJun -> ADAMTS4_mRNA + cFos_cJun cJun_dimer -> ADAMTS4_mRNA + cJun_dimer ADAMTS4_mRNA -> ADAMTS4 + ADAMTS4_mRNA ADAMTS4_mRNA -> Sink ADAMTS4 -> Sink cFos_cJun -> PP4 + cFos_cJun cJun_dimer -> PP4 + cJun_dimer cFos_cJun -> DUSP16 + cFos_cJun cJun_dimer -> DUSP16 + cJun_dimer PP4 -> Sink DUSP16 -> Sink PP4 + TRAF6 -> TRAF6_PP4 IRAK2_TRAF6 + PP4 -> IRAK2_TRAF6_PP4 TRAF6_PP4 -> PP4 + TRAF6 IRAK2_TRAF6_PP4 -> IRAK2_TRAF6 + PP4 cFos_cJun -> cFos_cJun + cFos_mRNA cFos_mRNA -> Sink cFos_mRNA -> cFos + cFos_mRNA cFos -> Sink cFos + p38_P -> cFos_P + p38_P cFos_P -> cFos cFos_cJun -> MKP1 + cFos_cJun cJun_dimer -> MKP1 + cJun_dimer MKP1 -> Sink DUSP16 + cFos_P -> DUSP16 + cFos cFos_P + cJun_P -> cFos_cJun cFos_cJun -> cFos_P + cJun_P OSM + OSMR -> OSM_OSMR OSM_OSMR -> OSM + OSMR OSM + OSMRa -> OSM_OSMRa OSM_OSMRa -> OSM + OSMRa JAK1 + OSM_OSMR -> JAK1_P + OSM_OSMR JAK1_P -> JAK1 JAK1_P + PTPRT -> JAK1 + PTPRT JAK1_P + STAT3_cyt -> JAK1_P + STAT3_P_cyt STAT3_P_cyt -> STAT3_cyt PTPRT + STAT3_P_cyt -> PTPRT + STAT3_cyt STAT3_P_nuc -> STAT3_nuc PTPRT + STAT3_P_nuc -> PTPRT + STAT3_nuc STAT3_P_cyt -> STAT3_P_nuc STAT3_nuc -> STAT3_cyt STAT3_P_nuc -> STAT3_P_nuc + cFos_mRNA STAT3_P_nuc -> PTPRT + STAT3_P_nuc PTPRT -> Sink STAT3_P_nuc -> SOCS3_mRNA + STAT3_P_nuc SOCS3_mRNA -> Sink SOCS3_mRNA -> SOCS3 + SOCS3_mRNA SOCS3 -> Sink OSMR + SOCS3 -> OSMR_SOCS3 OSMR_SOCS3 -> OSMR + SOCS3 OSM -> Sink MMP1 + TIMP1 -> MMP1_TIMP1 MMP1_TIMP1 -> MMP1 + TIMP1 MMP3 + TIMP1 -> MMP3_TIMP1 MMP3_TIMP1 -> MMP3 + TIMP1 MMP13 + TIMP1 -> MMP13_TIMP1 MMP13_TIMP1 -> MMP13 + TIMP1 ADAMTS4 + TIMP1 -> ADAMTS4_TIMP1 ADAMTS4_TIMP1 -> ADAMTS4 + TIMP1 Collagen2 + MMP1 -> ColFrag + MMP1 Collagen2 + MMP13 -> ColFrag + MMP13 ADAMTS4 + Aggrecan_Collagen2 -> ADAMTS4 + AggFrag + Collagen2 cFos_cJun -> Matriptase + cFos_cJun Matriptase -> Sink cFos_cJun -> SP1 + cFos_cJun SP1 -> Sink SP1 + TIMP1_DNA -> SP1_TIMP1_DNA SP1_TIMP1_DNA -> SP1 + TIMP1_DNA STAT3_P_nuc + TIMP1_DNA -> STAT3_P_nuc + TIMP1_DNA + TIMP1_mRNA TIMP1_DNA -> TIMP1_DNA + TIMP1_mRNA TIMP1_DNA + cFos_cJun -> TIMP1_DNA + TIMP1_mRNA + cFos_cJun Source -> TIMP3_mRNA cFos_cJun -> TIMP3_mRNA + cFos_cJun STAT3_P_nuc -> STAT3_P_nuc + TIMP3_mRNA TIMP3_mRNA -> TIMP3 + TIMP3_mRNA TIMP3_mRNA -> Sink TIMP3 -> Sink ADAMTS4 + TIMP3 -> ADAMTS4_TIMP3 ADAMTS4_TIMP3 -> ADAMTS4 + TIMP3 MMP1 + TIMP3 -> MMP1_TIMP3 MMP1_TIMP3 -> MMP1 + TIMP3 MMP3 + TIMP3 -> MMP3_TIMP3 MMP3_TIMP3 -> MMP3 + TIMP3 MMP13 + TIMP3 -> MMP13_TIMP3 MMP13_TIMP3 -> MMP13 + TIMP3