GLCex -> G6P G6P -> GLCex G6P + pAkt -> F16P + pAkt F16P + pAkt -> G6P + pAkt F16P -> PYRin PYRin -> LAC LAC -> PYRin PYRout -> PYRin PYRin -> PYRout PYRin -> OAA OAA + PEPCK -> F16P + PEPCK G6P + pAkt -> G1P + pAkt G1P + pAkt -> G6P + pAkt G1P + pGP -> GLY + pGP GLY + pGP -> G1P + pGP G6P + pGP -> G6P + GP 0 -> IRS IRS -> p1IRS p1IRS -> IRS p1IRS -> 0 p1IRS + pmTOR -> p1p2IRS + pmTOR p1p2IRS -> p1IRS IRS + pmTOR -> p2IRS + pmTOR p2IRS -> IRS p2IRS -> 0 p2IRS -> p1p2IRS p1p2IRS -> p2IRS p1p2IRS -> 0 Akt + p1IRS -> p1IRS + pAkt pAkt -> Akt mTOR + pAkt -> pAkt + pmTOR pmTOR -> mTOR Foxo + pAkt -> pAkt + pFoxo Foxo -> Foxo + mRNA mRNA -> PEPCK + mRNA pFoxo -> Foxo GP -> pGP