Source -> p53_mRNA p53_mRNA -> Sink Mdm2_mRNA -> Mdm2 + Mdm2_mRNA p53 -> Mdm2_mRNA + p53 p53_P -> Mdm2_mRNA + p53_P GSK3b_p53 -> GSK3b_p53 + Mdm2_mRNA GSK3b_p53_P -> GSK3b_p53_P + Mdm2_mRNA Mdm2_mRNA -> Sink Mdm2 + p53 -> Mdm2_p53 Mdm2_p53 -> Mdm2 + p53 GSK3b + p53 -> GSK3b_p53 GSK3b_p53 -> GSK3b + p53 GSK3b + p53_P -> GSK3b_p53_P GSK3b_p53_P -> GSK3b + p53_P ATP + E1 + Ub -> AMP + E1_Ub E1_Ub + E2 -> E1 + E2_Ub E2_Ub + Mdm2 -> E2 + Mdm2_Ub E2_Ub + Mdm2_Ub -> E2 + Mdm2_Ub2 E2_Ub + Mdm2_Ub2 -> E2 + Mdm2_Ub3 E2_Ub + Mdm2_Ub3 -> E2 + Mdm2_Ub4 Mdm2DUB + Mdm2_Ub4 -> Mdm2DUB + Mdm2_Ub3 + Ub Mdm2DUB + Mdm2_Ub3 -> Mdm2DUB + Mdm2_Ub2 + Ub Mdm2DUB + Mdm2_Ub2 -> Mdm2DUB + Mdm2_Ub + Ub Mdm2DUB + Mdm2_Ub -> Mdm2 + Mdm2DUB + Ub Mdm2_Ub4 + Proteasome -> Mdm2_Ub4_Proteasome Mdm2_Ub4_Proteasome -> Proteasome + 4*Ub p53_mRNA -> p53 + p53_mRNA E2_Ub + Mdm2_p53 -> E2 + Mdm2_p53_Ub E2_Ub + Mdm2_p53_Ub -> E2 + Mdm2_p53_Ub2 E2_Ub + Mdm2_p53_Ub2 -> E2 + Mdm2_p53_Ub3 E2_Ub + Mdm2_p53_Ub3 -> E2 + Mdm2_p53_Ub4 Mdm2_p53_Ub4 + p53DUB -> Mdm2_p53_Ub3 + Ub + p53DUB Mdm2_p53_Ub3 + p53DUB -> Mdm2_p53_Ub2 + Ub + p53DUB Mdm2_p53_Ub2 + p53DUB -> Mdm2_p53_Ub + Ub + p53DUB Mdm2_p53_Ub + p53DUB -> Mdm2_p53 + Ub + p53DUB GSK3b + Mdm2_p53_Ub4 -> GSK3b + Mdm2_P1_p53_Ub4 GSK3b_p53 + Mdm2_p53_Ub4 -> GSK3b_p53 + Mdm2_P1_p53_Ub4 GSK3b_p53_P + Mdm2_p53_Ub4 -> GSK3b_p53_P + Mdm2_P1_p53_Ub4 Mdm2_P1_p53_Ub4 + Proteasome -> Mdm2 + p53_Ub4_Proteasome ATP + p53_Ub4_Proteasome -> ADP + Proteasome + 4*Ub Tau -> MT_Tau MT_Tau -> Tau GSK3b_p53 + Tau -> GSK3b_p53 + Tau_P1 GSK3b_p53 + Tau_P1 -> GSK3b_p53 + Tau_P2 GSK3b_p53_P + Tau -> GSK3b_p53_P + Tau_P1 GSK3b_p53_P + Tau_P1 -> GSK3b_p53_P + Tau_P2 GSK3b + Tau -> GSK3b + Tau_P1 GSK3b + Tau_P1 -> GSK3b + Tau_P2 PP1 + Tau_P2 -> PP1 + Tau_P1 PP1 + Tau_P1 -> PP1 + Tau 2*Tau_P1 -> 2*AggTau AggTau + Tau_P1 -> 2*AggTau 2*Tau_P2 -> 2*AggTau AggTau + Tau_P2 -> 2*AggTau 2*Tau -> 2*AggTau AggTau + Tau -> 2*AggTau 2*AggTau -> 2*NFT AggTau + NFT -> 2*NFT AggTau + Proteasome -> AggTau_Proteasome GSK3b_p53 -> Abeta + GSK3b_p53 GSK3b_p53_P -> Abeta + GSK3b_p53_P AggAbeta + Proteasome -> AggAbeta_Proteasome Abeta -> Sink 2*Abeta -> AggAbeta Abeta + AggAbeta -> 2*AggAbeta 2*AggAbeta -> 2*AbetaPlaque AbetaPlaque + AggAbeta -> 2*AbetaPlaque Abeta -> Abeta + p53_mRNA 0 -> damDNA damDNA -> Sink ATMI + damDNA -> ATMA + damDNA ATMA + p53 -> ATMA + p53_P p53_P -> p53 ATMA + Mdm2 -> ATMA + Mdm2_P Mdm2_P -> Mdm2 E2_Ub + Mdm2_P -> E2 + Mdm2_P_Ub E2_Ub + Mdm2_P_Ub -> E2 + Mdm2_P_Ub2 E2_Ub + Mdm2_P_Ub2 -> E2 + Mdm2_P_Ub3 E2_Ub + Mdm2_P_Ub3 -> E2 + Mdm2_P_Ub4 Mdm2DUB + Mdm2_P_Ub4 -> Mdm2DUB + Mdm2_P_Ub3 + Ub Mdm2DUB + Mdm2_P_Ub3 -> Mdm2DUB + Mdm2_P_Ub2 + Ub Mdm2DUB + Mdm2_P_Ub2 -> Mdm2DUB + Mdm2_P_Ub + Ub Mdm2DUB + Mdm2_P_Ub -> Mdm2DUB + Mdm2_P + Ub Mdm2_P_Ub4 + Proteasome -> Mdm2_P_Ub4_Proteasome Mdm2_P_Ub4_Proteasome -> Proteasome + 4*Ub ATMA -> ATMI AggAbeta -> AggAbeta + ROS AggAbeta_Proteasome -> AggAbeta_Proteasome + ROS ROS -> ROS + damDNA basalROS -> basalROS + damDNA Source -> Tau Proteasome + Tau -> Proteasome_Tau Proteasome_Tau -> Proteasome