HRG + R -> RHRG RHRG -> HRG + R 2*RHRG -> RHRG2 RHRG2 -> 2*RHRG RHRG2 -> RP RP -> RHRG2 RP -> RHRG2 RP + Shc -> RShc RShc -> RP + Shc RShc -> RShP RShP -> RShc GS + RShP -> RShGS RShGS -> GS + RShP RShGS -> RP + ShGS RP + ShGS -> RShGS ShGS -> GS + ShP GS + ShP -> ShGS ShP -> Shc RasGDP -> RasGTP RasGTP -> RasGDP Raf -> Rafstar Rafstar -> Raf MEK -> MEKP MEKP -> MEK MEKP -> MEKPP MEKPP -> MEKP ERK -> ERKP ERKP -> ERK ERKP -> ERKPP ERKPP -> ERKP PI3K + RP -> RPI3K RPI3K -> PI3K + RP RPI3K -> RPI3Kstar RPI3Kstar -> RPI3K RPI3Kstar -> PI3Kstar + RP PI3Kstar + RP -> RPI3Kstar PI3Kstar -> PI3K Akt + PIP3 -> AktPIP3 AktPIP3 -> Akt + PIP3 PIP3 -> P_I P_I -> PIP3 AktPIP3 -> AktPIP AktPIP -> AktPIP3 AktPIP -> AktPIPP AktPIPP -> AktPIP RP -> internalization internalization -> RP