Cdc25_active -> Cdc25Ps216_active Cdc25Ps216_active -> Cdc25_active Cdc25_active -> Cdc25_inactive Cdc25_inactive -> Cdc25_active Cdc25Ps216_inactive -> Cdc25Ps216_active Cdc25Ps216_active -> Cdc25Ps216_inactive Cdc25_inactive -> Cdc25Ps216_inactive Cdc25Ps216_14_3_3_inactive -> Cdc25_inactive + protein_14_3_3 protein_14_3_3 -> 0 0 -> protein_14_3_3 0 -> protein_14_3_3 Cdc25Ps216_inactive + protein_14_3_3 -> Cdc25Ps216_14_3_3_inactive 0 -> p21 0 -> p21 p21 -> 0 MPF + p21 -> p21_MPF p21_MPF -> MPF + p21 preMPF -> MPF MPF -> preMPF MPF -> 0 0 -> preMPF Chk1 -> Chk1P Chk1P -> Chk1 0 -> Rad3_ATM Rad3_ATM -> 0 0 -> p53 p53 -> 0 0 -> Wee1 Wee1 -> Wee1_phosphorylated Wee1_phosphorylated -> Wee1 Wee1_phosphorylated -> 0 Cdc25Ps216_14_3_3_inactive -> 0 0 -> Cdc25_inactive