0 -> NaiveCD4 NaiveCD4 -> 0 0 -> nTreg nTreg -> 0 NaiveCD4 -> Tfh nTreg -> Tfr Tfh -> 0 Tfr -> 0 0 -> Bcl6 0 -> Blimp1 0 -> FoxP3 0 -> STAT3 0 -> STAT5 0 -> CXCR5 0 -> ICOS 0 -> IL2 0 -> IL4 0 -> IL6 0 -> IL10 Bcl6 -> 0 Blimp1 -> 0 FoxP3 -> 0 STAT3 -> 0 STAT5 -> 0 CXCR5 -> 0 ICOS -> 0 IL2 -> 0 IL4 -> 0 IL6 -> 0 IL10 -> 0 IL21 -> 0 0 -> IL21 0 -> TGFb TGFb -> 0 0 -> RXR 0 -> Tgif1 RXR -> 0 Tgif1 -> 0