Akt -> Akt_pS473 Akt_pS473 -> Akt AMPK -> AMPK_pT172 AMPK_pT172 -> AMPK AMPK_pT172 -> AMPK mTORC1 -> mTORC1_pS2448 mTORC1 -> mTORC1_pS2448 mTORC1_pS2448 -> mTORC1 0 -> Mitophagy Mitophagy -> Nil FoxO3a -> FoxO3a_pS253 FoxO3a_pS253 -> FoxO3a FoxO3a_pS253 -> Nil 0 -> FoxO3a 0 -> CDKN1A CDKN1A -> Nil 0 -> CDKN1B CDKN1B -> Nil 0 -> DNA_damage 0 -> DNA_damage DNA_damage -> Nil 0 -> ROS 0 -> ROS ROS -> Nil JNK -> JNK_pT183 JNK_pT183 -> JNK 0 -> SA_beta_gal 0 -> SA_beta_gal SA_beta_gal -> 0 Mito_mass_turnover -> Mito_mass_new Mito_mass_turnover -> Mito_mass_new Mito_mass_new -> Mito_mass_turnover Mito_mass_old -> Mito_mass_turnover Mito_mass_new -> Mito_mass_old 0 -> Mito_membr_pot_new 0 -> Mito_membr_pot_old Mito_membr_pot_new -> Nil Mito_membr_pot_old -> Nil 0 -> IKKbeta IKKbeta -> Nil mTORC1 -> mTORC1_pS2448