TNFR -> TNFR_E 0 -> TNFR TNFR_E -> 0 0 <-> RIP 0 <-> TRADD 0 <-> TRAF2 0 <-> FADD TNF_TNFR_E -> 0 TNF_TNFR_TRADD -> 0 TNFRC1 -> 0 TNFRC2 -> 0 TNFRC2_FLIP -> 0 TNFRC2_FLIP_FLIP -> 0 TNFRC2_pCasp8 -> 0 TNFRC2_pCasp8_pCasp8 -> 0 TNFRC2_FLIP_pCasp8 -> 0 TNFRC2_FLIP_pCasp8_RIP_TRAF2 -> 0 TNFR_E + TNF_E <-> TNF_TNFR_E TNF_TNFR_E + TRADD -> TNF_TNFR_TRADD RIP + TNF_TNFR_TRADD + TRAF2 -> TNFRC1 TNFRC1 -> TNFRCint1 TNFRCint1 -> RIP + TNFRCint2 + TRAF2 2*FADD + TNFRCint2 -> TNFRCint3 TNFRCint3 -> TNFRC2 FLIP + TNFRC2 -> TNFRC2_FLIP FLIP + TNFRC2_FLIP -> TNFRC2_FLIP_FLIP TNFRC2 + pCasp8 -> TNFRC2_pCasp8 TNFRC2_pCasp8 + pCasp8 -> TNFRC2_pCasp8_pCasp8 TNFRC2_pCasp8_pCasp8 -> Casp8 + TNFRC2 FLIP + TNFRC2_pCasp8 -> TNFRC2_FLIP_pCasp8 TNFRC2_FLIP + pCasp8 -> TNFRC2_FLIP_pCasp8 TNFRC2_FLIP_pCasp8 -> Casp8 + TNFRC2 RIP + TNFRC2_FLIP_pCasp8 + TRAF2 -> TNFRC2_FLIP_pCasp8_RIP_TRAF2 IKK -> IKKa 0 <-> IKK 0 <-> NFkB 0 <-> FLIP 0 <-> XIAP 0 <-> A20 IKKa -> 0 IkBa_NFkB -> 0 NFkB_N -> 0 IkBa_mRNA -> 0 IkBa -> 0 IkBa_N -> 0 IkBa_NFkB_N -> 0 PIkBa -> 0 A20_mRNA -> 0 XIAP_mRNA -> 0 FLIP_mRNA -> 0 IKK -> IKKa IKKa -> IKK TNFRC1 -> TNF_TNFR_TRADD + TRAF2 IkBa + NFkB -> IkBa_NFkB IkBa_NFkB -> NFkB + PIkBa NFkB -> NFkB_N 0 -> IkBa_mRNA 0 -> IkBa IkBa <-> IkBa_N IkBa_N + NFkB_N -> IkBa_NFkB_N IkBa_NFkB_N -> IkBa_NFkB 0 -> A20_mRNA 0 -> A20 0 -> XIAP_mRNA 0 -> XIAP 0 -> FLIP_mRNA 0 -> FLIP 0 <-> pCasp8 0 <-> pCasp3 0 <-> pCasp6 Casp8 -> 0 Casp3 -> 0 Casp6 -> 0 XIAP_Casp3 -> 0 0 <-> BAR BAR_Casp8 -> 0 PARP <-> 0 cPARP -> 0 pCasp3 -> Casp3 pCasp6 -> Casp6 pCasp8 -> Casp8 Casp3 + XIAP <-> XIAP_Casp3 XIAP -> 0 XIAP_Casp3 -> XIAP RIP -> 0 FLIP -> 0 PARP -> cPARP BAR + Casp8 <-> BAR_Casp8