Source -> p53_mRNA
p53_mRNA -> Sink
Mdm2_mRNA -> Mdm2 + Mdm2_mRNA
p53 -> Mdm2_mRNA + p53
p53_P -> Mdm2_mRNA + p53_P
GSK3b_p53 -> GSK3b_p53 + Mdm2_mRNA
GSK3b_p53_P -> GSK3b_p53_P + Mdm2_mRNA
Mdm2_mRNA -> Sink
Mdm2 + p53 -> Mdm2_p53
Mdm2_p53 -> Mdm2 + p53
GSK3b + p53 -> GSK3b_p53
GSK3b_p53 -> GSK3b + p53
GSK3b + p53_P -> GSK3b_p53_P
GSK3b_p53_P -> GSK3b + p53_P
ATP + E1 + Ub -> AMP + E1_Ub
E1_Ub + E2 -> E1 + E2_Ub
E2_Ub + Mdm2 -> E2 + Mdm2_Ub
E2_Ub + Mdm2_Ub -> E2 + Mdm2_Ub2
E2_Ub + Mdm2_Ub2 -> E2 + Mdm2_Ub3
E2_Ub + Mdm2_Ub3 -> E2 + Mdm2_Ub4
Mdm2DUB + Mdm2_Ub4 -> Mdm2DUB + Mdm2_Ub3 + Ub
Mdm2DUB + Mdm2_Ub3 -> Mdm2DUB + Mdm2_Ub2 + Ub
Mdm2DUB + Mdm2_Ub2 -> Mdm2DUB + Mdm2_Ub + Ub
Mdm2DUB + Mdm2_Ub -> Mdm2 + Mdm2DUB + Ub
Mdm2_Ub4 + Proteasome -> Mdm2_Ub4_Proteasome
Mdm2_Ub4_Proteasome -> Proteasome + 4*Ub
p53_mRNA -> p53 + p53_mRNA
E2_Ub + Mdm2_p53 -> E2 + Mdm2_p53_Ub
E2_Ub + Mdm2_p53_Ub -> E2 + Mdm2_p53_Ub2
E2_Ub + Mdm2_p53_Ub2 -> E2 + Mdm2_p53_Ub3
E2_Ub + Mdm2_p53_Ub3 -> E2 + Mdm2_p53_Ub4
Mdm2_p53_Ub4 + p53DUB -> Mdm2_p53_Ub3 + Ub + p53DUB
Mdm2_p53_Ub3 + p53DUB -> Mdm2_p53_Ub2 + Ub + p53DUB
Mdm2_p53_Ub2 + p53DUB -> Mdm2_p53_Ub + Ub + p53DUB
Mdm2_p53_Ub + p53DUB -> Mdm2_p53 + Ub + p53DUB
GSK3b + Mdm2_p53_Ub4 -> GSK3b + Mdm2_P1_p53_Ub4
GSK3b_p53 + Mdm2_p53_Ub4 -> GSK3b_p53 + Mdm2_P1_p53_Ub4
GSK3b_p53_P + Mdm2_p53_Ub4 -> GSK3b_p53_P + Mdm2_P1_p53_Ub4
Mdm2_P1_p53_Ub4 + Proteasome -> Mdm2 + p53_Ub4_Proteasome
ATP + p53_Ub4_Proteasome -> ADP + Proteasome + 4*Ub
Tau -> MT_Tau
MT_Tau -> Tau
GSK3b_p53 + Tau -> GSK3b_p53 + Tau_P1
GSK3b_p53 + Tau_P1 -> GSK3b_p53 + Tau_P2
GSK3b_p53_P + Tau -> GSK3b_p53_P + Tau_P1
GSK3b_p53_P + Tau_P1 -> GSK3b_p53_P + Tau_P2
GSK3b + Tau -> GSK3b + Tau_P1
GSK3b + Tau_P1 -> GSK3b + Tau_P2
PP1 + Tau_P2 -> PP1 + Tau_P1
PP1 + Tau_P1 -> PP1 + Tau
2*Tau_P1 -> 2*AggTau
AggTau + Tau_P1 -> 2*AggTau
2*Tau_P2 -> 2*AggTau
AggTau + Tau_P2 -> 2*AggTau
2*Tau -> 2*AggTau
AggTau + Tau -> 2*AggTau
2*AggTau -> 2*NFT
AggTau + NFT -> 2*NFT
AggTau + Proteasome -> AggTau_Proteasome
GSK3b_p53 -> Abeta + GSK3b_p53
GSK3b_p53_P -> Abeta + GSK3b_p53_P
AggAbeta + Proteasome -> AggAbeta_Proteasome
Abeta -> Sink
2*Abeta -> AggAbeta
Abeta + AggAbeta -> 2*AggAbeta
2*AggAbeta -> 2*AbetaPlaque
AbetaPlaque + AggAbeta -> 2*AbetaPlaque
Abeta -> Abeta + p53_mRNA
0 -> damDNA
damDNA -> Sink
ATMI + damDNA -> ATMA + damDNA
ATMA + p53 -> ATMA + p53_P
p53_P -> p53
ATMA + Mdm2 -> ATMA + Mdm2_P
Mdm2_P -> Mdm2
E2_Ub + Mdm2_P -> E2 + Mdm2_P_Ub
E2_Ub + Mdm2_P_Ub -> E2 + Mdm2_P_Ub2
E2_Ub + Mdm2_P_Ub2 -> E2 + Mdm2_P_Ub3
E2_Ub + Mdm2_P_Ub3 -> E2 + Mdm2_P_Ub4
Mdm2DUB + Mdm2_P_Ub4 -> Mdm2DUB + Mdm2_P_Ub3 + Ub
Mdm2DUB + Mdm2_P_Ub3 -> Mdm2DUB + Mdm2_P_Ub2 + Ub
Mdm2DUB + Mdm2_P_Ub2 -> Mdm2DUB + Mdm2_P_Ub + Ub
Mdm2DUB + Mdm2_P_Ub -> Mdm2DUB + Mdm2_P + Ub
Mdm2_P_Ub4 + Proteasome -> Mdm2_P_Ub4_Proteasome
Mdm2_P_Ub4_Proteasome -> Proteasome + 4*Ub
ATMA -> ATMI
AggAbeta -> AggAbeta + ROS
AggAbeta_Proteasome -> AggAbeta_Proteasome + ROS
ROS -> ROS + damDNA
basalROS -> basalROS + damDNA
Source -> Tau
Proteasome + Tau -> Proteasome_Tau
Proteasome_Tau -> Proteasome