HRG + R <-> RHRG 2*RHRG <-> RHRG2 RHRG2 <-> RP RP -> RHRG2 RP + Shc <-> RShc RShc <-> RShP GS + RShP <-> RShGS RShGS <-> RP + ShGS ShGS <-> GS + ShP ShP -> Shc RasGDP -> RasGTP RasGTP -> RasGDP Raf -> Rafstar Rafstar -> Raf MEK -> MEKP MEKP -> MEK MEKP -> MEKPP MEKPP -> MEKP ERK -> ERKP ERKP -> ERK ERKP -> ERKPP ERKPP -> ERKP PI3K + RP <-> RPI3K RPI3K <-> RPI3Kstar RPI3Kstar <-> PI3Kstar + RP PI3Kstar -> PI3K Akt + PIP3 <-> AktPIP3 PIP3 -> P_I P_I -> PIP3 AktPIP3 -> AktPIP AktPIP -> AktPIP3 AktPIP -> AktPIPP AktPIPP -> AktPIP RP <-> internalization