pro_EGFR <-> EGFR
EGF + EGFR <-> L_EGFR
2*L_EGFR <-> L_EGFR_dimer
Grb2 + SOS <-> SOS_Grb2
Grb2 + pSOS <-> pSOS_Grb2
L_EGFR_dimer <-> L_dpEGFR
L_dpEGFR + c_Cbl <-> dpEGFR_c_Cbl
L_dpEGFR + pShc <-> pShc_dpEGFR
pDok <-> Dok
c_Cbl + pShc_dpEGFR <-> pShc_dpEGFR_c_Cbl
pSOS -> SOS
pSOS_Grb2 -> SOS_Grb2
L_dpEGFR + Shc <-> Shc_dpEGFR
Shc_dpEGFR -> pShc_dpEGFR
dpEGFR_c_Cbl -> dpEGFR_c_Cbl_ubiq
dpEGFR_c_Cbl_ubiq -> c_Cbl + proteosome
Shc_dpEGFR + c_Cbl <-> Shc_dpEGFR_c_Cbl
Shc_dpEGFR_c_Cbl -> Shc_dpEGFR_c_Cbl_ubiq
Shc_dpEGFR_c_Cbl_ubiq -> Shc + c_Cbl + proteosome
pShc_dpEGFR_c_Cbl -> pShc_dpEGFR_c_Cbl_ubiq
pShc_dpEGFR_c_Cbl_ubiq -> c_Cbl + pShc + proteosome
Shc_dpEGFR_c_Cbl -> pShc_dpEGFR_c_Cbl
SOS_Grb2 + pShc <-> Grb2_SOS_pShc
Grb2_SOS_pShc + L_dpEGFR <-> Grb2_SOS_pShc_dpEGFR
SOS_Grb2 + pShc_dpEGFR <-> Grb2_SOS_pShc_dpEGFR
Grb2_SOS_pShc_dpEGFR + c_Cbl <-> Grb2_SOS_pShc_dpEGFR_c_Cbl
Grb2_SOS_pShc + dpEGFR_c_Cbl <-> Grb2_SOS_pShc_dpEGFR_c_Cbl
Grb2_SOS_pShc_dpEGFR_c_Cbl -> Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq
Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq -> Grb2_SOS_pShc + c_Cbl + proteosome
Grb2_SOS_pShc -> SOS_Grb2 + Shc
Dok -> pDok
pShc -> Shc
pFRS2 -> FRS2
C3G + Crk <-> Crk_C3G
FRS2 + L_dpEGFR <-> FRS2_dpEGFR
L_dpEGFR + pFRS2 <-> pFRS2_dpEGFR
FRS2_dpEGFR -> pFRS2_dpEGFR
Crk_C3G + pFRS2_dpEGFR <-> Crk_C3G_pFRS2_dpEGFR
FRS2_dpEGFR + c_Cbl <-> FRS2_dpEGFR_c_Cbl
c_Cbl + pFRS2_dpEGFR <-> pFRS2_dpEGFR_c_Cbl
pFRS2_dpEGFR_c_Cbl -> pFRS2_dpEGFR_c_Cbl_ubiq
FRS2_dpEGFR_c_Cbl -> FRS2_dpEGFR_c_Cbl_ubiq
FRS2_dpEGFR_c_Cbl -> pFRS2_dpEGFR_c_Cbl
Crk_C3G + pFRS2_dpEGFR_c_Cbl <-> Crk_C3G_pFRS2_dpEGFR_c_Cbl
Crk_C3G_pFRS2_dpEGFR_c_Cbl -> Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq
FRS2_dpEGFR_c_Cbl_ubiq -> FRS2 + c_Cbl + proteosome
pFRS2_dpEGFR_c_Cbl_ubiq -> c_Cbl + pFRS2 + proteosome
RasGAP + pDok <-> pDok_RasGAP
SOS_Grb2 -> pSOS_Grb2
SOS -> pSOS
Ras_GTP + c_Raf <-> c_Raf_Ras_GTP
B_Raf + Rap1_GTP <-> B_Raf_Rap1_GTP
B_Raf + Ras_GTP <-> B_Raf_Ras_GTP
ppMEK -> pMEK
pMEK -> MEK
ppMEK_ERK -> pMEK_ERK
pMEK_ERK -> MEK_ERK
2*ppERK <-> dppERK
Ras_GTP -> Ras_GDP
Rap1_GTP -> Rap1_GDP
Rap1_GDP -> Rap1_GTP
Ras_GDP -> Ras_GTP
NGF + NGFR <-> L_NGFR
L_NGFR -> pTrkA
pTrkA -> pTrkA_endo
pTrkA_endo -> degradation
pTrkA -> degradation
Shc + pTrkA <-> Shc_pTrkA
pShc + pTrkA <-> pShc_pTrkA
FRS2 + pTrkA <-> FRS2_pTrkA
pFRS2 + pTrkA <-> pFRS2_pTrkA
Shc + pTrkA_endo <-> Shc_pTrkA_endo
pShc + pTrkA_endo <-> pShc_pTrkA_endo
Shc_pTrkA_endo -> pShc_pTrkA_endo
Shc_pTrkA -> pShc_pTrkA
FRS2_pTrkA -> pFRS2_pTrkA
FRS2 + pTrkA_endo <-> FRS2_pTrkA_endo
pFRS2 + pTrkA_endo <-> pFRS2_pTrkA_endo
FRS2_pTrkA_endo -> pFRS2_pTrkA_endo
FRS2_pTrkA -> FRS2 + degradation
pFRS2_pTrkA -> degradation + pFRS2
Shc_pTrkA -> Shc + degradation
pShc_pTrkA -> degradation + pShc
FRS2_pTrkA_endo -> FRS2 + degradation
Shc_pTrkA_endo -> Shc + degradation
pShc_pTrkA_endo -> degradation + pShc
SOS_Grb2 + pShc_pTrkA_endo <-> Grb2_SOS_pShc_pTrkA_endo
SOS_Grb2 + pShc_pTrkA <-> Grb2_SOS_pShc_pTrkA
Grb2_SOS_pShc_pTrkA -> Grb2_SOS_pShc_pTrkA_endo
Crk_C3G_pFRS2_pTrkA -> Crk_C3G_pFRS2_pTrkA_endo
pFRS2_pTrkA -> pFRS2_pTrkA_endo
FRS2_pTrkA -> FRS2_pTrkA_endo
pShc_pTrkA -> pShc_pTrkA_endo
Shc_pTrkA -> Shc_pTrkA_endo
Crk_C3G + pFRS2_pTrkA <-> Crk_C3G_pFRS2_pTrkA
Crk_C3G + pFRS2_pTrkA_endo <-> Crk_C3G_pFRS2_pTrkA_endo
Grb2_SOS_pShc + pTrkA <-> Grb2_SOS_pShc_pTrkA
Grb2_SOS_pShc + pTrkA_endo <-> Grb2_SOS_pShc_pTrkA_endo
Crk_C3G_pFRS2_pTrkA -> Crk_C3G + degradation + pFRS2
Crk_C3G_pFRS2_pTrkA_endo -> Crk_C3G + degradation + pFRS2
Grb2_SOS_pShc_pTrkA -> Grb2_SOS_pShc + degradation
Grb2_SOS_pShc_pTrkA_endo -> Grb2_SOS_pShc + degradation
pFRS2_pTrkA_endo -> degradation + pFRS2
pro_TrkA <-> NGFR
Shc + dpEGFR_c_Cbl <-> Shc_dpEGFR_c_Cbl
dpEGFR_c_Cbl + pShc <-> pShc_dpEGFR_c_Cbl
SOS_Grb2 + pShc_dpEGFR_c_Cbl <-> Grb2_SOS_pShc_dpEGFR_c_Cbl
Crk_C3G_pFRS2_dpEGFR + c_Cbl <-> Crk_C3G_pFRS2_dpEGFR_c_Cbl
FRS2 + dpEGFR_c_Cbl <-> FRS2_dpEGFR_c_Cbl
dpEGFR_c_Cbl + pFRS2 <-> pFRS2_dpEGFR_c_Cbl
Ras_GTP -> Ras_GDP
Rap1_GTP -> Rap1_GDP
Dok -> pDok
Grb2_SOS_pShc -> pSOS_Grb2 + pShc
ERK + MEK <-> MEK_ERK
ERK + pMEK <-> pMEK_ERK
ERK + ppMEK <-> ppMEK_ERK
ppMEK_ERK -> ppERK + ppMEK
c_Raf_Ras_GTP -> Ras_GDP + c_Raf
B_Raf_Ras_GTP -> B_Raf + Ras_GDP
B_Raf_Rap1_GTP -> B_Raf + Rap1_GDP
MEK + c_Raf_Ras_GTP -> c_Raf_Ras_GTP_MEK
c_Raf_Ras_GTP + pMEK <-> c_Raf_Ras_GTP_pMEK
MEK_ERK + c_Raf_Ras_GTP <-> c_Raf_Ras_GTP_MEK_ERK
c_Raf_Ras_GTP + pMEK_ERK <-> c_Raf_Ras_GTP_pMEK_ERK
B_Raf_Ras_GTP + MEK <-> B_Raf_Ras_GTP_MEK
B_Raf_Ras_GTP + pMEK <-> B_Raf_Ras_GTP_pMEK
B_Raf_Ras_GTP + MEK_ERK <-> B_Raf_Ras_GTP_MEK_ERK
B_Raf_Ras_GTP + pMEK_ERK <-> B_Raf_Ras_GTP_pMEK_ERK
B_Raf_Rap1_GTP + MEK <-> B_Raf_Rap1_GTP_MEK
B_Raf_Rap1_GTP + pMEK <-> B_Raf_Rap1_GTP_pMEK
B_Raf_Rap1_GTP + MEK_ERK <-> B_Raf_Rap1_GTP_MEK_ERK
B_Raf_Rap1_GTP + pMEK_ERK <-> B_Raf_Rap1_GTP_pMEK_ERK
c_Raf_Ras_GTP_MEK -> c_Raf_Ras_GTP + pMEK
c_Raf_Ras_GTP_pMEK -> c_Raf_Ras_GTP + ppMEK
c_Raf_Ras_GTP_MEK_ERK -> c_Raf_Ras_GTP + pMEK_ERK
c_Raf_Ras_GTP_pMEK_ERK -> c_Raf_Ras_GTP + ppMEK_ERK
B_Raf_Ras_GTP_MEK -> B_Raf_Ras_GTP + pMEK
B_Raf_Ras_GTP_pMEK -> B_Raf_Ras_GTP + ppMEK
B_Raf_Ras_GTP_MEK_ERK -> B_Raf_Ras_GTP + pMEK_ERK
B_Raf_Ras_GTP_pMEK_ERK -> B_Raf_Ras_GTP + ppMEK_ERK
B_Raf_Rap1_GTP_MEK -> B_Raf_Rap1_GTP + pMEK
B_Raf_Rap1_GTP_pMEK -> B_Raf_Rap1_GTP + ppMEK
B_Raf_Rap1_GTP_MEK_ERK -> B_Raf_Rap1_GTP + pMEK_ERK
B_Raf_Rap1_GTP_pMEK_ERK -> B_Raf_Rap1_GTP + ppMEK_ERK
Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq -> Crk_C3G + c_Cbl + pFRS2
MKP3 + dppERK -> dppERK_MKP3
MKP3 + ppERK <-> ppERK_MKP3
ppERK_MKP3 -> ERK + MKP3
dppERK_MKP3 -> ERK + MKP3 + ppERK