M + MAPKK <-> M_MAPKK M_MAPKK -> MAPKK + Mp MAPKK + Mp <-> Mp_MAPKK Mp_MAPKK -> MAPKK + Mpp MKP3 + Mpp <-> Mpp_MKP3 Mpp_MKP3 -> Mp_MKP3_dep Mp_MKP3_dep <-> MKP3 + Mp MKP3 + Mp <-> Mp_MKP3 Mp_MKP3 -> M_MKP3 M_MKP3 <-> M + MKP3