{ diff(x1, t) = (1*k188*k28*k4 + (-1)*k188*k11*x1*x4*k4 + 1*k188*k12*x6*k4 + (-1)*k188*k19*x1/(k15 + x1)*(x10 + x11)*k4 + 1*k188*k20*x2/(k16 + x2)*k4 + (-1)*k188*k8*x2*k4)/k188,
  diff(x2, t) = (1*k188*k19*x1/(k15 + x1)*(x10 + x11)*k4 + (-1)*k188*k20*x2/(k16 + x2)*k4 + (-1)*k188*k21*x2/(k17 + x2)*x14*k4 + 1*k188*k22*x3/(k18 + x3)*k4 + (-1)*k188*k13*x2*x4*k4 + 1*k188*k14*x7*k4 + (-1)*k188*k9*x2*k4)/k188,
  diff(x3, t) = (1*k188*k21*x2/(k17 + x2)*x14*k4 + (-1)*k188*k22*x3/(k18 + x3)*k4 + (-1)*k188*k10*x3*k4)/k188,
  diff(x4, t) = ((-1)*k188*k11*x1*x4*k4 + 1*k188*k12*x6*k4 + (-1)*k188*k13*x2*x4*k4 + 1*k188*k14*x7*k4 + 1*k188*k27*k4 + (-1)*k188*k25*x4/(k23 + x4)*x21*k4 + 1*k188*k26*x5/(k24 + x5)*k4 + (-1)*k188*k6*x4*k4)/k188,
  diff(x5, t) = (1*k188*k25*x4/(k23 + x4)*x21*k4 + (-1)*k188*k26*x5/(k24 + x5)*k4 + (-1)*k188*k7*x5*k4)/k188,
  diff(x6, t) = (1*k188*k11*x1*x4*k4 + (-1)*k188*k12*x6*k4)/k188,
  diff(x7, t) = (1*k188*k13*x2*x4*k4 + (-1)*k188*k14*x7*k4)/k188,
  diff(x8, t) = (1*k188*k32*x44*k4 + 1*k188*k33*x4*k30/(k30 + x1)*k31/(k31 + x2)*k4 + (-1)*k188*k35*x8*(k29 - (x9 + x10 + x11))*k4 + 1*k188*k34*x9*k4 + (-1)*k188*k42*x8/(k39 + x8)*k4 + (-1)*k188*k38*x8*k4)/k188,
  diff(x9, t) = (1*k188*k35*x8*(k29 - (x9 + x10 + x11))*k4 + (-1)*k188*k34*x9*k4 + 1*k188*k44*x10/(k41 + x10)*k4 + (-1)*k188*k43*x9/(k40 + x9)*k4)/k188,
  diff(x10, t) = ((-1)*k188*k44*x10/(k41 + x10)*k4 + 1*k188*k43*x9/(k40 + x9)*k4 + (-1)*k188*k36*x10*x23*k4 + 1*k188*k37*x11*k4)/k188,
  diff(x11, t) = (1*k188*k36*x10*x23*k4 + (-1)*k188*k37*x11*k4)/k188,
  diff(x12, t) = (1*k188*k50*x4*k48/(k48 + x1)*k49/(k49 + x2)*k4 + (-1)*k188*k54*x12*(k46 - (x13 + x14 + x16 + x20 + x21 + x22))*k4 + 1*k188*k53*x13*k4 + (-1)*k188*k67*x15/(k60 + x15)*x12/(k59 + x12)*k4 + (-1)*k188*k55*x12*k4)/k188,
  diff(x13, t) = (1*k188*k54*x12*(k46 - (x13 + x14 + x16 + x20 + x21 + x22))*k4 + (-1)*k188*k53*x13*k4 + 1*k188*k70*(x37 + k47)*x14/(k64 + x14)*k4 + (-1)*k188*k69*x13/(k63 + x13)*x18*k4)/k188,
  diff(x14, t) = ((-1)*k188*k70*(x37 + k47)*x14/(k64 + x14)*k4 + 1*k188*k69*x13/(k63 + x13)*x18*k4 + (-1)*k188*k51*x14*x23*k4 + 1*k188*k52*x16*k4)/k188,
  diff(x15, t) = (1*k188*k74*k4 + (-1)*k188*k68*x15/(k61 + x15)*x26/(k62 + x26)*k4 + (-1)*k188*k56*x15*k4)/k188,
  diff(x16, t) = (1*k188*k51*x14*x23*k4 + (-1)*k188*k52*x16*k4)/k188,
  diff(x17, t) = (1*k188*k73*k4 + 1*k188*k72*(k75 + k76*x42)*x18/(k66 + x18)*k4 + (-1)*k188*k71*(x14 + k45)*x17/(k65 + x17)*k4 + (-1)*k188*k58*x17*k4)/k188,
  diff(x18, t) = ((-1)*k188*k72*(k75 + k76*x42)*x18/(k66 + x18)*k4 + 1*k188*k71*(x14 + k45)*x17/(k65 + x17)*k4 + (-1)*k188*k57*x18*k4)/k188,
  diff(x19, t) = (1*k188*k83*x4*k79/(k79 + x1)*k80/(k80 + x2)*k4 + (-1)*k188*k85*x19*(k46 - (x13 + x14 + x16 + x20 + x21 + x22))*k4 + 1*k188*k84*x20*k4 + (-1)*k188*k108*x19/(k95 + x19)*x34/(k98 + x34)*k4 + (-1)*k188*k88*x19*k4)/k188,
  diff(x20, t) = (1*k188*k85*x19*(k46 - (x13 + x14 + x16 + x20 + x21 + x22))*k4 + (-1)*k188*k84*x20*k4 + 1*k188*k110*(x37 + k78)*x21/(k100 + x21)*k4 + (-1)*k188*k109*x20/(k99 + x20)*x28*k4)/k188,
  diff(x21, t) = ((-1)*k188*k110*(x37 + k78)*x21/(k100 + x21)*k4 + 1*k188*k109*x20/(k99 + x20)*x28*k4 + (-1)*k188*k86*x21*x23*k4 + 1*k188*k87*x22*k4)/k188,
  diff(x22, t) = (1*k188*k86*x21*x23*k4 + (-1)*k188*k87*x22*k4)/k188,
  diff(x23, t) = ((-1)*k188*k36*x10*x23*k4 + 1*k188*k37*x11*k4 + (-1)*k188*k51*x14*x23*k4 + 1*k188*k52*x16*k4 + (-1)*k188*k86*x21*x23*k4 + 1*k188*k87*x22*k4 + 1*k188*k115*k4 + 1*k188*k116*x4*k81/(k81 + x1)*k82/(k82 + x2)*k4 + (-1)*k188*k127*x31*x23*k4 + 1*k188*k128*x32*k4 + (-1)*k188*k119*x23/(k105 + x23)*x14*k4 + 1*k188*k120*x24/(k106 + x24)*k4 + (-1)*k188*k89*x23*k4)/k188,
  diff(x24, t) = (1*k188*k119*x23/(k105 + x23)*x14*k4 + (-1)*k188*k120*x24/(k106 + x24)*k4 + (-1)*k188*k107*x15/(k97 + x15)*x24/(k96 + x24)*k4 + (-1)*k188*k90*x24*k4)/k188,
  diff(x25, t) = (1*k188*k118*x26/(k102 + x26)*(x21 + x31)*k4 + (-1)*k188*k117*x25/(k101 + x25)*k4 + (-1)*k188*k92*x25*k4)/k188,
  diff(x26, t) = ((-1)*k188*k118*x26/(k102 + x26)*(x21 + x31)*k4 + 1*k188*k117*x25/(k101 + x25)*k4 + (-1)*k188*k91*x26*k4 + 1*k188*k113*k4)/k188,
  diff(x27, t) = (1*k188*k112*(k121 + k122*x42)*x28/(k104 + x28)*k4 + (-1)*k188*k111*(x21 + k77)*x27/(k103 + x27)*k4 + (-1)*k188*k94*x27*k4 + 1*k188*k114*k4)/k188,
  diff(x28, t) = ((-1)*k188*k112*(k121 + k122*x42)*x28/(k104 + x28)*k4 + 1*k188*k111*(x21 + k77)*x27/(k103 + x27)*k4 + (-1)*k188*k93*x28*k4)/k188,
  diff(x29, t) = (1*k188*k150*k4 + (-1)*k188*k130*x29*(k124 - (x30 + x31 + x32))*k4 + 1*k188*k129*x30*k4 + (-1)*k188*k151*x29/(k138 + x29)*x34/(k139 + x34)*k4 + (-1)*k188*k133*x29*k4 + (-1)*k188*k151*x29/(k138 + x29)*x26/(k140 + x26)*k4)/k188,
  diff(x30, t) = (1*k188*k130*x29*(k124 - (x30 + x31 + x32))*k4 + (-1)*k188*k129*x30*k4 + 1*k188*k153*(x37 + k126)*x31/(k143 + x31)*k4 + (-1)*k188*k152*x30/(k142 + x30)*x36*k4)/k188,
  diff(x31, t) = ((-1)*k188*k127*x31*x23*k4 + 1*k188*k128*x32*k4 + (-1)*k188*k153*(x37 + k126)*x31/(k143 + x31)*k4 + 1*k188*k152*x30/(k142 + x30)*x36*k4)/k188,
  diff(x32, t) = (1*k188*k127*x31*x23*k4 + (-1)*k188*k128*x32*k4)/k188,
  diff(x33, t) = (1*k188*k154*k4 + (-1)*k188*k155*x33/(k144 + x33)*x31*k4 + 1*k188*k156*x34/(k145 + x34)*k4 + (-1)*k188*k132*x33*k4)/k188,
  diff(x34, t) = (1*k188*k155*x33/(k144 + x33)*x31*k4 + (-1)*k188*k156*x34/(k145 + x34)*k4 + (-1)*k188*k131*x34*k4)/k188,
  diff(x35, t) = (1*k188*k161*k4 + 1*k188*k158*(k163 + k164*x42)*x36/(k147 + x36)*k4 + (-1)*k188*k157*(x31 + k123)*x35/(k146 + x35)*k4 + (-1)*k188*k135*x35*k4)/k188,
  diff(x36, t) = ((-1)*k188*k158*(k163 + k164*x42)*x36/(k147 + x36)*k4 + 1*k188*k157*(x31 + k123)*x35/(k146 + x35)*k4 + (-1)*k188*k134*x36*k4)/k188,
  diff(x37, t) = (1*k188*k162*k4 + 1*k188*k141*x45*k4 + (-1)*k188*k159*(x31 + k125)*x37/(k148 + x37)*k4 + 1*k188*k160*x38/(k149 + x38)*k4 + (-1)*k188*k136*x37*k4)/k188,
  diff(x38, t) = (1*k188*k159*(x31 + k125)*x37/(k148 + x37)*k4 + (-1)*k188*k160*x38/(k149 + x38)*k4 + (-1)*k188*k137*x38*k4)/k188,
  diff(x39, t) = (1*k188*k172*(k178 - x39)*x40*k4 + (-1)*k188*k170*x39*k4)/k188,
  diff(x40, t) = (1*k188*k179*x14*(k167 - x40)/(k174 + k167 - x40)*k4 + (-1)*k188*k180*x40/(k175 + x40)*k4 + (-1)*k188*k172*(k178 - x39)*x40*k4 + 1*k188*k170*x39*k4)/k188,
  diff(x41, t) = (1*k188*k173*x39*k4 + (-1)*k188*k171*x41*k4 + (-1)*k188*k168*(k165 - x43)*x41*k4 + 1*k188*k169*x43*k4)/k188,
  diff(x42, t) = (1*k188*k181*x43*(k166 - x42)/(k176 + k166 - x42)*k4 + (-1)*k188*k182*x42/(k177 + x42)*k4)/k188,
  diff(x43, t) = (1*k188*k168*(k165 - x43)*x41*k4 + (-1)*k188*k169*x43*k4)/k188,
  diff(x44, t) = (1*k188*k5*k1/(k2 + k1)*k4 + (-1)*k188*k3*x44*k4)/k188,
  diff(x45, t) = 0/k188 }