\frac{dx_{1}}{dt} = \left(1 \cdot k_{188} \cdot k_{28} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{11} \cdot x_{1} \cdot x_{4} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{12} \cdot x_{6} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{19} \cdot x_{1} / \left(k_{15} + x_{1}\right) \cdot \left(x_{10} + x_{11}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{20} \cdot x_{2} / \left(k_{16} + x_{2}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{8} \cdot x_{2} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{2}}{dt} = \left(1 \cdot k_{188} \cdot k_{19} \cdot x_{1} / \left(k_{15} + x_{1}\right) \cdot \left(x_{10} + x_{11}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{20} \cdot x_{2} / \left(k_{16} + x_{2}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{21} \cdot x_{2} / \left(k_{17} + x_{2}\right) \cdot x_{14} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{22} \cdot x_{3} / \left(k_{18} + x_{3}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{13} \cdot x_{2} \cdot x_{4} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{14} \cdot x_{7} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{9} \cdot x_{2} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{3}}{dt} = \left(1 \cdot k_{188} \cdot k_{21} \cdot x_{2} / \left(k_{17} + x_{2}\right) \cdot x_{14} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{22} \cdot x_{3} / \left(k_{18} + x_{3}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{10} \cdot x_{3} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{4}}{dt} = \left(-1 \cdot k_{188} \cdot k_{11} \cdot x_{1} \cdot x_{4} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{12} \cdot x_{6} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{13} \cdot x_{2} \cdot x_{4} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{14} \cdot x_{7} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{27} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{25} \cdot x_{4} / \left(k_{23} + x_{4}\right) \cdot x_{21} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{26} \cdot x_{5} / \left(k_{24} + x_{5}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{6} \cdot x_{4} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{5}}{dt} = \left(1 \cdot k_{188} \cdot k_{25} \cdot x_{4} / \left(k_{23} + x_{4}\right) \cdot x_{21} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{26} \cdot x_{5} / \left(k_{24} + x_{5}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{7} \cdot x_{5} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{6}}{dt} = \left(1 \cdot k_{188} \cdot k_{11} \cdot x_{1} \cdot x_{4} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{12} \cdot x_{6} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{7}}{dt} = \left(1 \cdot k_{188} \cdot k_{13} \cdot x_{2} \cdot x_{4} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{14} \cdot x_{7} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{8}}{dt} = \left(1 \cdot k_{188} \cdot k_{32} \cdot x_{44} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{33} \cdot x_{4} \cdot k_{30} / \left(k_{30} + x_{1}\right) \cdot k_{31} / \left(k_{31} + x_{2}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{35} \cdot x_{8} \cdot \left(k_{29} - \left(x_{9} + x_{10} + x_{11}\right)\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{34} \cdot x_{9} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{42} \cdot x_{8} / \left(k_{39} + x_{8}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{38} \cdot x_{8} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{9}}{dt} = \left(1 \cdot k_{188} \cdot k_{35} \cdot x_{8} \cdot \left(k_{29} - \left(x_{9} + x_{10} + x_{11}\right)\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{34} \cdot x_{9} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{44} \cdot x_{10} / \left(k_{41} + x_{10}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{43} \cdot x_{9} / \left(k_{40} + x_{9}\right) \cdot k_{4}\right) / k_{188}\\
\frac{dx_{10}}{dt} = \left(-1 \cdot k_{188} \cdot k_{44} \cdot x_{10} / \left(k_{41} + x_{10}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{43} \cdot x_{9} / \left(k_{40} + x_{9}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{36} \cdot x_{10} \cdot x_{23} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{37} \cdot x_{11} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{11}}{dt} = \left(1 \cdot k_{188} \cdot k_{36} \cdot x_{10} \cdot x_{23} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{37} \cdot x_{11} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{12}}{dt} = \left(1 \cdot k_{188} \cdot k_{50} \cdot x_{4} \cdot k_{48} / \left(k_{48} + x_{1}\right) \cdot k_{49} / \left(k_{49} + x_{2}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{54} \cdot x_{12} \cdot \left(k_{46} - \left(x_{13} + x_{14} + x_{16} + x_{20} + x_{21} + x_{22}\right)\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{53} \cdot x_{13} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{67} \cdot x_{15} / \left(k_{60} + x_{15}\right) \cdot x_{12} / \left(k_{59} + x_{12}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{55} \cdot x_{12} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{13}}{dt} = \left(1 \cdot k_{188} \cdot k_{54} \cdot x_{12} \cdot \left(k_{46} - \left(x_{13} + x_{14} + x_{16} + x_{20} + x_{21} + x_{22}\right)\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{53} \cdot x_{13} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{70} \cdot \left(x_{37} + k_{47}\right) \cdot x_{14} / \left(k_{64} + x_{14}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{69} \cdot x_{13} / \left(k_{63} + x_{13}\right) \cdot x_{18} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{14}}{dt} = \left(-1 \cdot k_{188} \cdot k_{70} \cdot \left(x_{37} + k_{47}\right) \cdot x_{14} / \left(k_{64} + x_{14}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{69} \cdot x_{13} / \left(k_{63} + x_{13}\right) \cdot x_{18} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{51} \cdot x_{14} \cdot x_{23} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{52} \cdot x_{16} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{15}}{dt} = \left(1 \cdot k_{188} \cdot k_{74} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{68} \cdot x_{15} / \left(k_{61} + x_{15}\right) \cdot x_{26} / \left(k_{62} + x_{26}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{56} \cdot x_{15} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{16}}{dt} = \left(1 \cdot k_{188} \cdot k_{51} \cdot x_{14} \cdot x_{23} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{52} \cdot x_{16} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{17}}{dt} = \left(1 \cdot k_{188} \cdot k_{73} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{72} \cdot \left(k_{75} + k_{76} \cdot x_{42}\right) \cdot x_{18} / \left(k_{66} + x_{18}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{71} \cdot \left(x_{14} + k_{45}\right) \cdot x_{17} / \left(k_{65} + x_{17}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{58} \cdot x_{17} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{18}}{dt} = \left(-1 \cdot k_{188} \cdot k_{72} \cdot \left(k_{75} + k_{76} \cdot x_{42}\right) \cdot x_{18} / \left(k_{66} + x_{18}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{71} \cdot \left(x_{14} + k_{45}\right) \cdot x_{17} / \left(k_{65} + x_{17}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{57} \cdot x_{18} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{19}}{dt} = \left(1 \cdot k_{188} \cdot k_{83} \cdot x_{4} \cdot k_{79} / \left(k_{79} + x_{1}\right) \cdot k_{80} / \left(k_{80} + x_{2}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{85} \cdot x_{19} \cdot \left(k_{46} - \left(x_{13} + x_{14} + x_{16} + x_{20} + x_{21} + x_{22}\right)\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{84} \cdot x_{20} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{108} \cdot x_{19} / \left(k_{95} + x_{19}\right) \cdot x_{34} / \left(k_{98} + x_{34}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{88} \cdot x_{19} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{20}}{dt} = \left(1 \cdot k_{188} \cdot k_{85} \cdot x_{19} \cdot \left(k_{46} - \left(x_{13} + x_{14} + x_{16} + x_{20} + x_{21} + x_{22}\right)\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{84} \cdot x_{20} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{110} \cdot \left(x_{37} + k_{78}\right) \cdot x_{21} / \left(k_{100} + x_{21}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{109} \cdot x_{20} / \left(k_{99} + x_{20}\right) \cdot x_{28} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{21}}{dt} = \left(-1 \cdot k_{188} \cdot k_{110} \cdot \left(x_{37} + k_{78}\right) \cdot x_{21} / \left(k_{100} + x_{21}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{109} \cdot x_{20} / \left(k_{99} + x_{20}\right) \cdot x_{28} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{86} \cdot x_{21} \cdot x_{23} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{87} \cdot x_{22} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{22}}{dt} = \left(1 \cdot k_{188} \cdot k_{86} \cdot x_{21} \cdot x_{23} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{87} \cdot x_{22} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{23}}{dt} = \left(-1 \cdot k_{188} \cdot k_{36} \cdot x_{10} \cdot x_{23} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{37} \cdot x_{11} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{51} \cdot x_{14} \cdot x_{23} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{52} \cdot x_{16} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{86} \cdot x_{21} \cdot x_{23} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{87} \cdot x_{22} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{115} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{116} \cdot x_{4} \cdot k_{81} / \left(k_{81} + x_{1}\right) \cdot k_{82} / \left(k_{82} + x_{2}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{127} \cdot x_{31} \cdot x_{23} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{128} \cdot x_{32} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{119} \cdot x_{23} / \left(k_{105} + x_{23}\right) \cdot x_{14} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{120} \cdot x_{24} / \left(k_{106} + x_{24}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{89} \cdot x_{23} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{24}}{dt} = \left(1 \cdot k_{188} \cdot k_{119} \cdot x_{23} / \left(k_{105} + x_{23}\right) \cdot x_{14} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{120} \cdot x_{24} / \left(k_{106} + x_{24}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{107} \cdot x_{15} / \left(k_{97} + x_{15}\right) \cdot x_{24} / \left(k_{96} + x_{24}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{90} \cdot x_{24} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{25}}{dt} = \left(1 \cdot k_{188} \cdot k_{118} \cdot x_{26} / \left(k_{102} + x_{26}\right) \cdot \left(x_{21} + x_{31}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{117} \cdot x_{25} / \left(k_{101} + x_{25}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{92} \cdot x_{25} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{26}}{dt} = \left(-1 \cdot k_{188} \cdot k_{118} \cdot x_{26} / \left(k_{102} + x_{26}\right) \cdot \left(x_{21} + x_{31}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{117} \cdot x_{25} / \left(k_{101} + x_{25}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{91} \cdot x_{26} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{113} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{27}}{dt} = \left(1 \cdot k_{188} \cdot k_{112} \cdot \left(k_{121} + k_{122} \cdot x_{42}\right) \cdot x_{28} / \left(k_{104} + x_{28}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{111} \cdot \left(x_{21} + k_{77}\right) \cdot x_{27} / \left(k_{103} + x_{27}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{94} \cdot x_{27} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{114} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{28}}{dt} = \left(-1 \cdot k_{188} \cdot k_{112} \cdot \left(k_{121} + k_{122} \cdot x_{42}\right) \cdot x_{28} / \left(k_{104} + x_{28}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{111} \cdot \left(x_{21} + k_{77}\right) \cdot x_{27} / \left(k_{103} + x_{27}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{93} \cdot x_{28} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{29}}{dt} = \left(1 \cdot k_{188} \cdot k_{150} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{130} \cdot x_{29} \cdot \left(k_{124} - \left(x_{30} + x_{31} + x_{32}\right)\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{129} \cdot x_{30} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{151} \cdot x_{29} / \left(k_{138} + x_{29}\right) \cdot x_{34} / \left(k_{139} + x_{34}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{133} \cdot x_{29} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{151} \cdot x_{29} / \left(k_{138} + x_{29}\right) \cdot x_{26} / \left(k_{140} + x_{26}\right) \cdot k_{4}\right) / k_{188}\\
\frac{dx_{30}}{dt} = \left(1 \cdot k_{188} \cdot k_{130} \cdot x_{29} \cdot \left(k_{124} - \left(x_{30} + x_{31} + x_{32}\right)\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{129} \cdot x_{30} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{153} \cdot \left(x_{37} + k_{126}\right) \cdot x_{31} / \left(k_{143} + x_{31}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{152} \cdot x_{30} / \left(k_{142} + x_{30}\right) \cdot x_{36} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{31}}{dt} = \left(-1 \cdot k_{188} \cdot k_{127} \cdot x_{31} \cdot x_{23} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{128} \cdot x_{32} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{153} \cdot \left(x_{37} + k_{126}\right) \cdot x_{31} / \left(k_{143} + x_{31}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{152} \cdot x_{30} / \left(k_{142} + x_{30}\right) \cdot x_{36} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{32}}{dt} = \left(1 \cdot k_{188} \cdot k_{127} \cdot x_{31} \cdot x_{23} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{128} \cdot x_{32} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{33}}{dt} = \left(1 \cdot k_{188} \cdot k_{154} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{155} \cdot x_{33} / \left(k_{144} + x_{33}\right) \cdot x_{31} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{156} \cdot x_{34} / \left(k_{145} + x_{34}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{132} \cdot x_{33} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{34}}{dt} = \left(1 \cdot k_{188} \cdot k_{155} \cdot x_{33} / \left(k_{144} + x_{33}\right) \cdot x_{31} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{156} \cdot x_{34} / \left(k_{145} + x_{34}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{131} \cdot x_{34} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{35}}{dt} = \left(1 \cdot k_{188} \cdot k_{161} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{158} \cdot \left(k_{163} + k_{164} \cdot x_{42}\right) \cdot x_{36} / \left(k_{147} + x_{36}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{157} \cdot \left(x_{31} + k_{123}\right) \cdot x_{35} / \left(k_{146} + x_{35}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{135} \cdot x_{35} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{36}}{dt} = \left(-1 \cdot k_{188} \cdot k_{158} \cdot \left(k_{163} + k_{164} \cdot x_{42}\right) \cdot x_{36} / \left(k_{147} + x_{36}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{157} \cdot \left(x_{31} + k_{123}\right) \cdot x_{35} / \left(k_{146} + x_{35}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{134} \cdot x_{36} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{37}}{dt} = \left(1 \cdot k_{188} \cdot k_{162} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{141} \cdot x_{45} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{159} \cdot \left(x_{31} + k_{125}\right) \cdot x_{37} / \left(k_{148} + x_{37}\right) \cdot k_{4} + 1 \cdot k_{188} \cdot k_{160} \cdot x_{38} / \left(k_{149} + x_{38}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{136} \cdot x_{37} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{38}}{dt} = \left(1 \cdot k_{188} \cdot k_{159} \cdot \left(x_{31} + k_{125}\right) \cdot x_{37} / \left(k_{148} + x_{37}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{160} \cdot x_{38} / \left(k_{149} + x_{38}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{137} \cdot x_{38} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{39}}{dt} = \left(1 \cdot k_{188} \cdot k_{172} \cdot \left(k_{178} - x_{39}\right) \cdot x_{40} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{170} \cdot x_{39} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{40}}{dt} = \left(1 \cdot k_{188} \cdot k_{179} \cdot x_{14} \cdot \left(k_{167} - x_{40}\right) / \left(k_{174} + k_{167} - x_{40}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{180} \cdot x_{40} / \left(k_{175} + x_{40}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{172} \cdot \left(k_{178} - x_{39}\right) \cdot x_{40} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{170} \cdot x_{39} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{41}}{dt} = \left(1 \cdot k_{188} \cdot k_{173} \cdot x_{39} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{171} \cdot x_{41} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{168} \cdot \left(k_{165} - x_{43}\right) \cdot x_{41} \cdot k_{4} + 1 \cdot k_{188} \cdot k_{169} \cdot x_{43} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{42}}{dt} = \left(1 \cdot k_{188} \cdot k_{181} \cdot x_{43} \cdot \left(k_{166} - x_{42}\right) / \left(k_{176} + k_{166} - x_{42}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{182} \cdot x_{42} / \left(k_{177} + x_{42}\right) \cdot k_{4}\right) / k_{188}\\
\frac{dx_{43}}{dt} = \left(1 \cdot k_{188} \cdot k_{168} \cdot \left(k_{165} - x_{43}\right) \cdot x_{41} \cdot k_{4} + -1 \cdot k_{188} \cdot k_{169} \cdot x_{43} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{44}}{dt} = \left(1 \cdot k_{188} \cdot k_{5} \cdot k_{1} / \left(k_{2} + k_{1}\right) \cdot k_{4} + -1 \cdot k_{188} \cdot k_{3} \cdot x_{44} \cdot k_{4}\right) / k_{188}\\
\frac{dx_{45}}{dt} = 0 / k_{188}