\frac{dx_{1}}{dt} = \left(1 \cdot \left(k_{120} \cdot k_{245} - k_{88} \cdot x_{1}\right) + -1 \cdot \left(k_{237} \cdot x_{1} \cdot k_{223} - k_{238} \cdot x_{67} \cdot k_{224}\right) + -1 \cdot \left(k_{241} \cdot x_{61} \cdot x_{1} - k_{242} \cdot x_{64}\right)\right) / k_{223}\\
\frac{dx_{2}}{dt} = \left(-1 \cdot k_{180} \cdot x_{2} + 1 \cdot \left(k_{235} \cdot x_{71} \cdot k_{224} - k_{236} \cdot x_{2} \cdot k_{223}\right) + -1 \cdot \left(k_{239} \cdot x_{2} \cdot x_{61} - k_{240} \cdot x_{63}\right)\right) / k_{223}\\
\frac{dx_{3}}{dt} = \left(1 \cdot k_{180} \cdot x_{2} + -1 \cdot k_{190} \cdot x_{3} + -1 \cdot \left(k_{222} \cdot x_{17} \cdot x_{3} - k_{93} \cdot x_{5}\right) + -1 \cdot \left(k_{169} \cdot x_{58} \cdot x_{3} - k_{94} \cdot x_{7}\right) + -1 \cdot \left(k_{170} \cdot x_{18} \cdot x_{3} - k_{95} \cdot x_{9}\right) + -1 \cdot \left(k_{174} \cdot x_{19} \cdot x_{3} - k_{99} \cdot x_{11}\right) + -1 \cdot \left(k_{175} \cdot x_{60} \cdot x_{3} - k_{100} \cdot x_{13}\right) + -1 \cdot k_{183} \cdot x_{3}\right) / k_{223}\\
\frac{dx_{4}}{dt} = \left(1 \cdot k_{190} \cdot x_{3} + -1 \cdot k_{126} \cdot x_{4} + -1 \cdot \left(k_{171} \cdot x_{17} \cdot x_{4} - k_{96} \cdot x_{6}\right) + -1 \cdot \left(k_{172} \cdot x_{58} \cdot x_{4} - k_{97} \cdot x_{8}\right) + -1 \cdot \left(k_{173} \cdot x_{18} \cdot x_{4} - k_{98} \cdot x_{10}\right) + -1 \cdot \left(k_{176} \cdot x_{19} \cdot x_{4} - k_{101} \cdot x_{12}\right) + -1 \cdot \left(k_{177} \cdot x_{60} \cdot x_{4} - k_{102} \cdot x_{14}\right)\right) / k_{223}\\
\frac{dx_{5}}{dt} = \left(-1 \cdot k_{195} \cdot x_{5} + 1 \cdot \left(k_{222} \cdot x_{17} \cdot x_{3} - k_{93} \cdot x_{5}\right) + -1 \cdot k_{178} \cdot x_{5} + -1 \cdot k_{184} \cdot x_{5}\right) / k_{223}\\
\frac{dx_{6}}{dt} = \left(1 \cdot k_{195} \cdot x_{5} + -1 \cdot k_{137} \cdot x_{6} + 1 \cdot \left(k_{171} \cdot x_{17} \cdot x_{4} - k_{96} \cdot x_{6}\right) + -1 \cdot k_{179} \cdot x_{6}\right) / k_{223}\\
\frac{dx_{7}}{dt} = \left(-1 \cdot k_{204} \cdot x_{7} + 1 \cdot \left(k_{169} \cdot x_{58} \cdot x_{3} - k_{94} \cdot x_{7}\right) + 1 \cdot k_{178} \cdot x_{5} + -1 \cdot k_{185} \cdot x_{7} + -1 \cdot \left(k_{194} \cdot x_{25} \cdot x_{7} - k_{106} \cdot x_{9}\right)\right) / k_{223}\\
\frac{dx_{8}}{dt} = \left(1 \cdot k_{204} \cdot x_{7} + -1 \cdot k_{148} \cdot x_{8} + 1 \cdot \left(k_{172} \cdot x_{58} \cdot x_{4} - k_{97} \cdot x_{8}\right) + 1 \cdot k_{179} \cdot x_{6} + -1 \cdot \left(k_{196} \cdot x_{25} \cdot x_{8} - k_{107} \cdot x_{10}\right)\right) / k_{223}\\
\frac{dx_{9}}{dt} = \left(-1 \cdot k_{210} \cdot x_{9} + 1 \cdot \left(k_{170} \cdot x_{18} \cdot x_{3} - k_{95} \cdot x_{9}\right) + -1 \cdot k_{186} \cdot x_{9} + 1 \cdot \left(k_{194} \cdot x_{25} \cdot x_{7} - k_{106} \cdot x_{9}\right)\right) / k_{223}\\
\frac{dx_{10}}{dt} = \left(1 \cdot k_{210} \cdot x_{9} + -1 \cdot k_{159} \cdot x_{10} + 1 \cdot \left(k_{173} \cdot x_{18} \cdot x_{4} - k_{98} \cdot x_{10}\right) + 1 \cdot \left(k_{196} \cdot x_{25} \cdot x_{8} - k_{107} \cdot x_{10}\right)\right) / k_{223}\\
\frac{dx_{11}}{dt} = \left(-1 \cdot k_{218} \cdot x_{11} + 1 \cdot \left(k_{174} \cdot x_{19} \cdot x_{3} - k_{99} \cdot x_{11}\right) + -1 \cdot k_{181} \cdot x_{11} + -1 \cdot k_{187} \cdot x_{11}\right) / k_{223}\\
\frac{dx_{12}}{dt} = \left(1 \cdot k_{218} \cdot x_{11} + -1 \cdot k_{166} \cdot x_{12} + 1 \cdot \left(k_{176} \cdot x_{19} \cdot x_{4} - k_{101} \cdot x_{12}\right) + -1 \cdot k_{182} \cdot x_{12}\right) / k_{223}\\
\frac{dx_{13}}{dt} = \left(-1 \cdot k_{220} \cdot x_{13} + 1 \cdot \left(k_{175} \cdot x_{60} \cdot x_{3} - k_{100} \cdot x_{13}\right) + 1 \cdot k_{181} \cdot x_{11} + -1 \cdot k_{188} \cdot x_{13} + -1 \cdot \left(k_{206} \cdot x_{20} \cdot x_{13} - k_{111} \cdot x_{15}\right)\right) / k_{223}\\
\frac{dx_{14}}{dt} = \left(1 \cdot k_{220} \cdot x_{13} + -1 \cdot k_{167} \cdot x_{14} + 1 \cdot \left(k_{177} \cdot x_{60} \cdot x_{4} - k_{102} \cdot x_{14}\right) + 1 \cdot k_{182} \cdot x_{12} + -1 \cdot \left(k_{207} \cdot x_{20} \cdot x_{14} - k_{112} \cdot x_{16}\right)\right) / k_{223}\\
\frac{dx_{15}}{dt} = \left(-1 \cdot k_{121} \cdot x_{15} + -1 \cdot k_{189} \cdot x_{15} + 1 \cdot \left(k_{206} \cdot x_{20} \cdot x_{13} - k_{111} \cdot x_{15}\right)\right) / k_{223}\\
\frac{dx_{16}}{dt} = \left(1 \cdot k_{121} \cdot x_{15} + -1 \cdot k_{168} \cdot x_{16} + 1 \cdot \left(k_{207} \cdot x_{20} \cdot x_{14} - k_{112} \cdot x_{16}\right)\right) / k_{223}\\
\frac{dx_{17}}{dt} = \left(1 \cdot k_{137} \cdot x_{6} + -1 \cdot \left(k_{222} \cdot x_{17} \cdot x_{3} - k_{93} \cdot x_{5}\right) + -1 \cdot \left(k_{171} \cdot x_{17} \cdot x_{4} - k_{96} \cdot x_{6}\right) + 1 \cdot k_{184} \cdot x_{5} + 1 \cdot k_{197} \cdot x_{58} + 1 \cdot k_{198} \cdot x_{18}\right) / k_{223}\\
\frac{dx_{18}}{dt} = \left(1 \cdot k_{159} \cdot x_{10} + -1 \cdot \left(k_{170} \cdot x_{18} \cdot x_{3} - k_{95} \cdot x_{9}\right) + -1 \cdot \left(k_{173} \cdot x_{18} \cdot x_{4} - k_{98} \cdot x_{10}\right) + 1 \cdot k_{186} \cdot x_{9} + 1 \cdot \left(k_{193} \cdot x_{25} \cdot x_{58} - k_{105} \cdot x_{18}\right) + -1 \cdot k_{198} \cdot x_{18} + -1 \cdot k_{62} \cdot x_{35} \cdot x_{18} / \left(k_{16} + x_{18}\right)\right) / k_{223}\\
\frac{dx_{19}}{dt} = \left(1 \cdot k_{166} \cdot x_{12} + -1 \cdot \left(k_{174} \cdot x_{19} \cdot x_{3} - k_{99} \cdot x_{11}\right) + -1 \cdot \left(k_{176} \cdot x_{19} \cdot x_{4} - k_{101} \cdot x_{12}\right) + 1 \cdot k_{187} \cdot x_{11} + 1 \cdot k_{208} \cdot x_{60}\right) / k_{223}\\
\frac{dx_{20}}{dt} = \left(1 \cdot k_{168} \cdot x_{16} + 1 \cdot k_{189} \cdot x_{15} + 1 \cdot \left(k_{205} \cdot x_{54} \cdot x_{53} - k_{110} \cdot x_{20}\right) + -1 \cdot \left(k_{206} \cdot x_{20} \cdot x_{13} - k_{111} \cdot x_{15}\right) + -1 \cdot \left(k_{207} \cdot x_{20} \cdot x_{14} - k_{112} \cdot x_{16}\right)\right) / k_{223}\\
\frac{dx_{21}}{dt} = \left(-1 \cdot k_{53} \cdot x_{3} \cdot x_{21} / \left(k_{7} + x_{21}\right) + -1 \cdot k_{54} \cdot x_{5} \cdot x_{21} / \left(k_{8} + x_{21}\right) + -1 \cdot k_{55} \cdot x_{7} \cdot x_{21} / \left(k_{9} + x_{21}\right) + -1 \cdot k_{56} \cdot x_{9} \cdot x_{21} / \left(k_{10} + x_{21}\right) + -1 \cdot k_{57} \cdot x_{11} \cdot x_{21} / \left(k_{11} + x_{21}\right) + -1 \cdot k_{58} \cdot x_{13} \cdot x_{21} / \left(k_{12} + x_{21}\right) + -1 \cdot k_{59} \cdot x_{15} \cdot x_{21} / \left(k_{13} + x_{21}\right) + 1 \cdot \left(k_{202} \cdot x_{22} - k_{109} \cdot x_{21}\right)\right) / k_{223}\\
\frac{dx_{22}}{dt} = \left(1 \cdot k_{53} \cdot x_{3} \cdot x_{21} / \left(k_{7} + x_{21}\right) + 1 \cdot k_{54} \cdot x_{5} \cdot x_{21} / \left(k_{8} + x_{21}\right) + 1 \cdot k_{55} \cdot x_{7} \cdot x_{21} / \left(k_{9} + x_{21}\right) + 1 \cdot k_{56} \cdot x_{9} \cdot x_{21} / \left(k_{10} + x_{21}\right) + 1 \cdot k_{57} \cdot x_{11} \cdot x_{21} / \left(k_{11} + x_{21}\right) + 1 \cdot k_{58} \cdot x_{13} \cdot x_{21} / \left(k_{12} + x_{21}\right) + 1 \cdot k_{59} \cdot x_{15} \cdot x_{21} / \left(k_{13} + x_{21}\right) + -1 \cdot \left(k_{201} \cdot x_{22} \cdot x_{56} - k_{108} \cdot x_{55}\right) + -1 \cdot \left(k_{202} \cdot x_{22} - k_{109} \cdot x_{21}\right)\right) / k_{223}\\
\frac{dx_{23}}{dt} = \left(-1 \cdot \left(k_{191} \cdot x_{23} \cdot x_{24} - k_{103} \cdot x_{25}\right) + -1 \cdot \left(k_{192} \cdot x_{23} \cdot x_{59} - k_{104} \cdot x_{57}\right)\right) / k_{223}\\
\frac{dx_{24}}{dt} = \left(-1 \cdot \left(k_{191} \cdot x_{23} \cdot x_{24} - k_{103} \cdot x_{25}\right) + 1 \cdot k_{199} \cdot x_{59} + -1 \cdot k_{61} \cdot x_{35} \cdot x_{24} / \left(k_{15} + x_{24}\right)\right) / k_{223}\\
\frac{dx_{25}}{dt} = \left(1 \cdot \left(k_{191} \cdot x_{23} \cdot x_{24} - k_{103} \cdot x_{25}\right) + -1 \cdot \left(k_{193} \cdot x_{25} \cdot x_{58} - k_{105} \cdot x_{18}\right) + -1 \cdot \left(k_{194} \cdot x_{25} \cdot x_{7} - k_{106} \cdot x_{9}\right) + -1 \cdot \left(k_{196} \cdot x_{25} \cdot x_{8} - k_{107} \cdot x_{10}\right) + 1 \cdot k_{198} \cdot x_{18} + 1 \cdot k_{200} \cdot x_{57} + -1 \cdot k_{63} \cdot x_{35} \cdot x_{25} / \left(k_{17} + x_{25}\right)\right) / k_{223}\\
\frac{dx_{26}}{dt} = \left(-1 \cdot k_{203} \cdot x_{26} + 1 \cdot k_{60} \cdot x_{9} \cdot x_{27} / \left(k_{14} + x_{27}\right) + -1 \cdot k_{64} \cdot x_{55} \cdot x_{26} / \left(k_{18} + x_{26}\right) + -1 \cdot \left(k_{211} \cdot x_{30} \cdot x_{26} - k_{113} \cdot x_{50}\right) + -1 \cdot \left(k_{212} \cdot x_{29} \cdot x_{26} - k_{114} \cdot x_{28}\right)\right) / k_{223}\\
\frac{dx_{27}}{dt} = \left(1 \cdot k_{203} \cdot x_{26} + -1 \cdot k_{60} \cdot x_{9} \cdot x_{27} / \left(k_{14} + x_{27}\right) + 1 \cdot k_{64} \cdot x_{55} \cdot x_{26} / \left(k_{18} + x_{26}\right) + 1 \cdot k_{65} \cdot x_{55} \cdot x_{28} / \left(k_{19} + x_{28}\right) + 1 \cdot k_{66} \cdot x_{55} \cdot x_{50} / \left(k_{20} + x_{50}\right)\right) / k_{223}\\
\frac{dx_{28}}{dt} = \left(-1 \cdot k_{65} \cdot x_{55} \cdot x_{28} / \left(k_{19} + x_{28}\right) + 1 \cdot \left(k_{212} \cdot x_{29} \cdot x_{26} - k_{114} \cdot x_{28}\right)\right) / k_{223}\\
\frac{dx_{29}}{dt} = \left(1 \cdot k_{65} \cdot x_{55} \cdot x_{28} / \left(k_{19} + x_{28}\right) + 1 \cdot k_{69} \cdot k_{46} \cdot x_{51} / \left(k_{23} + x_{51}\right) + -1 \cdot \left(k_{212} \cdot x_{29} \cdot x_{26} - k_{114} \cdot x_{28}\right) + -1 \cdot \left(k_{213} \cdot x_{29} \cdot x_{31} - k_{115} \cdot x_{51}\right)\right) / k_{223}\\
\frac{dx_{30}}{dt} = \left(1 \cdot k_{66} \cdot x_{55} \cdot x_{50} / \left(k_{20} + x_{50}\right) + -1 \cdot \left(k_{211} \cdot x_{30} \cdot x_{26} - k_{113} \cdot x_{50}\right)\right) / k_{223}\\
\frac{dx_{31}}{dt} = \left(-1 \cdot k_{209} \cdot x_{31} + 1 \cdot k_{67} \cdot x_{16} \cdot x_{52} / \left(k_{21} + x_{52}\right) + -1 \cdot k_{68} \cdot k_{46} \cdot x_{31} / \left(k_{22} + x_{31}\right) + -1 \cdot \left(k_{213} \cdot x_{29} \cdot x_{31} - k_{115} \cdot x_{51}\right)\right) / k_{223}\\
\frac{dx_{32}}{dt} = \left(-1 \cdot k_{214} \cdot x_{32} + 1 \cdot \left(k_{219} \cdot x_{33} \cdot x_{37} - k_{119} \cdot x_{32}\right) + 1 \cdot k_{73} \cdot x_{50} \cdot x_{40} / \left(k_{27} + x_{40}\right) + 1 \cdot k_{77} \cdot x_{28} \cdot x_{40} / \left(k_{31} + x_{40}\right) + 1 \cdot k_{81} \cdot x_{51} \cdot x_{40} / \left(k_{35} + x_{40}\right) + -1 \cdot k_{85} \cdot k_{44} \cdot x_{32} / \left(k_{39} + x_{32}\right) + -1 \cdot k_{153} \cdot x_{32} + 1 \cdot k_{155} \cdot x_{41}\right) / k_{223}\\
\frac{dx_{33}}{dt} = \left(1 \cdot k_{214} \cdot x_{32} + -1 \cdot \left(k_{219} \cdot x_{33} \cdot x_{37} - k_{119} \cdot x_{32}\right) + 1 \cdot k_{71} \cdot x_{50} \cdot x_{39} / \left(k_{25} + x_{39}\right) + 1 \cdot k_{75} \cdot x_{28} \cdot x_{39} / \left(k_{29} + x_{39}\right) + 1 \cdot k_{79} \cdot x_{51} \cdot x_{39} / \left(k_{33} + x_{39}\right) + -1 \cdot k_{83} \cdot k_{44} \cdot x_{33} / \left(k_{37} + x_{33}\right) + -1 \cdot k_{149} \cdot x_{33} + 1 \cdot k_{151} \cdot x_{42}\right) / k_{223}\\
\frac{dx_{34}}{dt} = \left(1 \cdot k_{214} \cdot x_{32} + -2 \cdot \left(k_{215} \cdot x_{34} \cdot x_{34} - k_{116} \cdot x_{35}\right) + -1 \cdot k_{86} \cdot k_{42} \cdot x_{34} / \left(k_{40} + x_{34}\right) + 1 \cdot k_{87} \cdot k_{42} \cdot x_{35} / \left(k_{41} + x_{35}\right) + -1 \cdot k_{144} \cdot x_{34} + 1 \cdot k_{146} \cdot x_{43}\right) / k_{223}\\
\frac{dx_{35}}{dt} = \left(1 \cdot \left(k_{215} \cdot x_{34} \cdot x_{34} - k_{116} \cdot x_{35}\right) + -1 \cdot k_{87} \cdot k_{42} \cdot x_{35} / \left(k_{41} + x_{35}\right) + -1 \cdot k_{157} \cdot x_{35} + 1 \cdot k_{160} \cdot x_{44}\right) / k_{223}\\
\frac{dx_{36}}{dt} = \left(-1 \cdot \left(k_{216} \cdot x_{36} \cdot x_{37} - k_{117} \cdot x_{38}\right) + -1 \cdot k_{70} \cdot x_{50} \cdot x_{36} / \left(k_{24} + x_{36}\right) + -1 \cdot k_{74} \cdot x_{28} \cdot x_{36} / \left(k_{28} + x_{36}\right) + -1 \cdot k_{78} \cdot x_{51} \cdot x_{36} / \left(k_{32} + x_{36}\right) + 1 \cdot k_{82} \cdot k_{44} \cdot x_{39} / \left(k_{36} + x_{39}\right) + -1 \cdot k_{140} \cdot x_{36} + 1 \cdot k_{142} \cdot x_{45}\right) / k_{223}\\
\frac{dx_{37}}{dt} = \left(-1 \cdot \left(k_{216} \cdot x_{36} \cdot x_{37} - k_{117} \cdot x_{38}\right) + -1 \cdot \left(k_{217} \cdot x_{39} \cdot x_{37} - k_{118} \cdot x_{40}\right) + -1 \cdot \left(k_{219} \cdot x_{33} \cdot x_{37} - k_{119} \cdot x_{32}\right) + 1 \cdot k_{86} \cdot k_{42} \cdot x_{34} / \left(k_{40} + x_{34}\right) + 1 \cdot k_{87} \cdot k_{42} \cdot x_{35} / \left(k_{41} + x_{35}\right) + -1 \cdot k_{135} \cdot x_{37} + 1 \cdot k_{138} \cdot x_{46}\right) / k_{223}\\
\frac{dx_{38}}{dt} = \left(1 \cdot \left(k_{216} \cdot x_{36} \cdot x_{37} - k_{117} \cdot x_{38}\right) + -1 \cdot k_{72} \cdot x_{50} \cdot x_{38} / \left(k_{26} + x_{38}\right) + -1 \cdot k_{76} \cdot x_{28} \cdot x_{38} / \left(k_{30} + x_{38}\right) + -1 \cdot k_{80} \cdot x_{51} \cdot x_{38} / \left(k_{34} + x_{38}\right) + 1 \cdot k_{84} \cdot k_{44} \cdot x_{40} / \left(k_{38} + x_{40}\right) + -1 \cdot k_{131} \cdot x_{38} + 1 \cdot k_{133} \cdot x_{47}\right) / k_{223}\\
\frac{dx_{39}}{dt} = \left(-1 \cdot \left(k_{217} \cdot x_{39} \cdot x_{37} - k_{118} \cdot x_{40}\right) + 1 \cdot k_{70} \cdot x_{50} \cdot x_{36} / \left(k_{24} + x_{36}\right) + -1 \cdot k_{71} \cdot x_{50} \cdot x_{39} / \left(k_{25} + x_{39}\right) + 1 \cdot k_{74} \cdot x_{28} \cdot x_{36} / \left(k_{28} + x_{36}\right) + -1 \cdot k_{75} \cdot x_{28} \cdot x_{39} / \left(k_{29} + x_{39}\right) + 1 \cdot k_{78} \cdot x_{51} \cdot x_{36} / \left(k_{32} + x_{36}\right) + -1 \cdot k_{79} \cdot x_{51} \cdot x_{39} / \left(k_{33} + x_{39}\right) + -1 \cdot k_{82} \cdot k_{44} \cdot x_{39} / \left(k_{36} + x_{39}\right) + 1 \cdot k_{83} \cdot k_{44} \cdot x_{33} / \left(k_{37} + x_{33}\right) + -1 \cdot k_{127} \cdot x_{39} + 1 \cdot k_{129} \cdot x_{48}\right) / k_{223}\\
\frac{dx_{40}}{dt} = \left(1 \cdot \left(k_{217} \cdot x_{39} \cdot x_{37} - k_{118} \cdot x_{40}\right) + 1 \cdot k_{72} \cdot x_{50} \cdot x_{38} / \left(k_{26} + x_{38}\right) + -1 \cdot k_{73} \cdot x_{50} \cdot x_{40} / \left(k_{27} + x_{40}\right) + 1 \cdot k_{76} \cdot x_{28} \cdot x_{38} / \left(k_{30} + x_{38}\right) + -1 \cdot k_{77} \cdot x_{28} \cdot x_{40} / \left(k_{31} + x_{40}\right) + 1 \cdot k_{80} \cdot x_{51} \cdot x_{38} / \left(k_{34} + x_{38}\right) + -1 \cdot k_{81} \cdot x_{51} \cdot x_{40} / \left(k_{35} + x_{40}\right) + -1 \cdot k_{84} \cdot k_{44} \cdot x_{40} / \left(k_{38} + x_{40}\right) + 1 \cdot k_{85} \cdot k_{44} \cdot x_{32} / \left(k_{39} + x_{32}\right) + -1 \cdot k_{162} \cdot x_{40} + 1 \cdot k_{164} \cdot x_{49}\right) / k_{223}\\
\frac{dx_{41}}{dt} = \left(-1 \cdot k_{221} \cdot x_{41} + 1 \cdot \left(k_{125} \cdot x_{42} \cdot x_{46} - k_{92} \cdot x_{41}\right) + -1 \cdot k_{50} \cdot k_{45} \cdot x_{41} / \left(k_{4} + x_{41}\right) + 1 \cdot k_{154} \cdot x_{32} + -1 \cdot k_{156} \cdot x_{41}\right) / k_{223}\\
\frac{dx_{42}}{dt} = \left(1 \cdot k_{221} \cdot x_{41} + -1 \cdot \left(k_{125} \cdot x_{42} \cdot x_{46} - k_{92} \cdot x_{41}\right) + -1 \cdot k_{48} \cdot k_{45} \cdot x_{42} / \left(k_{2} + x_{42}\right) + 1 \cdot k_{150} \cdot x_{33} + -1 \cdot k_{152} \cdot x_{42}\right) / k_{223}\\
\frac{dx_{43}}{dt} = \left(1 \cdot k_{221} \cdot x_{41} + -2 \cdot \left(k_{122} \cdot x_{43} \cdot x_{43} - k_{89} \cdot x_{44}\right) + -1 \cdot k_{51} \cdot k_{43} \cdot x_{43} / \left(k_{5} + x_{43}\right) + 1 \cdot k_{52} \cdot k_{43} \cdot x_{44} / \left(k_{6} + x_{44}\right) + 1 \cdot k_{145} \cdot x_{34} + -1 \cdot k_{147} \cdot x_{43}\right) / k_{223}\\
\frac{dx_{44}}{dt} = \left(1 \cdot \left(k_{122} \cdot x_{43} \cdot x_{43} - k_{89} \cdot x_{44}\right) + -1 \cdot k_{52} \cdot k_{43} \cdot x_{44} / \left(k_{6} + x_{44}\right) + 1 \cdot k_{158} \cdot x_{35} + -1 \cdot k_{161} \cdot x_{44}\right) / k_{223}\\
\frac{dx_{45}}{dt} = \left(-1 \cdot \left(k_{123} \cdot x_{45} \cdot x_{46} - k_{90} \cdot x_{47}\right) + 1 \cdot k_{47} \cdot k_{45} \cdot x_{48} / \left(k_{1} + x_{48}\right) + 1 \cdot k_{141} \cdot x_{36} + -1 \cdot k_{143} \cdot x_{45}\right) / k_{223}\\
\frac{dx_{46}}{dt} = \left(-1 \cdot \left(k_{123} \cdot x_{45} \cdot x_{46} - k_{90} \cdot x_{47}\right) + -1 \cdot \left(k_{124} \cdot x_{48} \cdot x_{46} - k_{91} \cdot x_{49}\right) + -1 \cdot \left(k_{125} \cdot x_{42} \cdot x_{46} - k_{92} \cdot x_{41}\right) + 1 \cdot k_{51} \cdot k_{43} \cdot x_{43} / \left(k_{5} + x_{43}\right) + 1 \cdot k_{52} \cdot k_{43} \cdot x_{44} / \left(k_{6} + x_{44}\right) + 1 \cdot k_{136} \cdot x_{37} + -1 \cdot k_{139} \cdot x_{46}\right) / k_{223}\\
\frac{dx_{47}}{dt} = \left(1 \cdot \left(k_{123} \cdot x_{45} \cdot x_{46} - k_{90} \cdot x_{47}\right) + 1 \cdot k_{49} \cdot k_{45} \cdot x_{49} / \left(k_{3} + x_{49}\right) + 1 \cdot k_{132} \cdot x_{38} + -1 \cdot k_{134} \cdot x_{47}\right) / k_{223}\\
\frac{dx_{48}}{dt} = \left(-1 \cdot \left(k_{124} \cdot x_{48} \cdot x_{46} - k_{91} \cdot x_{49}\right) + -1 \cdot k_{47} \cdot k_{45} \cdot x_{48} / \left(k_{1} + x_{48}\right) + 1 \cdot k_{48} \cdot k_{45} \cdot x_{42} / \left(k_{2} + x_{42}\right) + 1 \cdot k_{128} \cdot x_{39} + -1 \cdot k_{130} \cdot x_{48}\right) / k_{223}\\
\frac{dx_{49}}{dt} = \left(1 \cdot \left(k_{124} \cdot x_{48} \cdot x_{46} - k_{91} \cdot x_{49}\right) + -1 \cdot k_{49} \cdot k_{45} \cdot x_{49} / \left(k_{3} + x_{49}\right) + 1 \cdot k_{50} \cdot k_{45} \cdot x_{41} / \left(k_{4} + x_{41}\right) + 1 \cdot k_{163} \cdot x_{40} + -1 \cdot k_{165} \cdot x_{49}\right) / k_{223}\\
\frac{dx_{50}}{dt} = \left(-1 \cdot k_{66} \cdot x_{55} \cdot x_{50} / \left(k_{20} + x_{50}\right) + 1 \cdot \left(k_{211} \cdot x_{30} \cdot x_{26} - k_{113} \cdot x_{50}\right)\right) / k_{223}\\
\frac{dx_{51}}{dt} = \left(-1 \cdot k_{69} \cdot k_{46} \cdot x_{51} / \left(k_{23} + x_{51}\right) + 1 \cdot \left(k_{213} \cdot x_{29} \cdot x_{31} - k_{115} \cdot x_{51}\right)\right) / k_{223}\\
\frac{dx_{52}}{dt} = \left(1 \cdot k_{209} \cdot x_{31} + -1 \cdot k_{67} \cdot x_{16} \cdot x_{52} / \left(k_{21} + x_{52}\right) + 1 \cdot k_{68} \cdot k_{46} \cdot x_{31} / \left(k_{22} + x_{31}\right) + 1 \cdot k_{69} \cdot k_{46} \cdot x_{51} / \left(k_{23} + x_{51}\right)\right) / k_{223}\\
\frac{dx_{53}}{dt} = -1 \cdot \left(k_{205} \cdot x_{54} \cdot x_{53} - k_{110} \cdot x_{20}\right) / k_{223}\\
\frac{dx_{54}}{dt} = -1 \cdot \left(k_{205} \cdot x_{54} \cdot x_{53} - k_{110} \cdot x_{20}\right) / k_{223}\\
\frac{dx_{55}}{dt} = 1 \cdot \left(k_{201} \cdot x_{22} \cdot x_{56} - k_{108} \cdot x_{55}\right) / k_{223}\\
\frac{dx_{56}}{dt} = -1 \cdot \left(k_{201} \cdot x_{22} \cdot x_{56} - k_{108} \cdot x_{55}\right) / k_{223}\\
\frac{dx_{57}}{dt} = \left(1 \cdot \left(k_{192} \cdot x_{23} \cdot x_{59} - k_{104} \cdot x_{57}\right) + -1 \cdot k_{200} \cdot x_{57} + 1 \cdot k_{62} \cdot x_{35} \cdot x_{18} / \left(k_{16} + x_{18}\right) + 1 \cdot k_{63} \cdot x_{35} \cdot x_{25} / \left(k_{17} + x_{25}\right)\right) / k_{223}\\
\frac{dx_{58}}{dt} = \left(1 \cdot k_{148} \cdot x_{8} + -1 \cdot \left(k_{169} \cdot x_{58} \cdot x_{3} - k_{94} \cdot x_{7}\right) + -1 \cdot \left(k_{172} \cdot x_{58} \cdot x_{4} - k_{97} \cdot x_{8}\right) + 1 \cdot k_{185} \cdot x_{7} + -1 \cdot \left(k_{193} \cdot x_{25} \cdot x_{58} - k_{105} \cdot x_{18}\right) + -1 \cdot k_{197} \cdot x_{58} + 1 \cdot k_{62} \cdot x_{35} \cdot x_{18} / \left(k_{16} + x_{18}\right)\right) / k_{223}\\
\frac{dx_{59}}{dt} = \left(-1 \cdot \left(k_{192} \cdot x_{23} \cdot x_{59} - k_{104} \cdot x_{57}\right) + -1 \cdot k_{199} \cdot x_{59} + 1 \cdot k_{61} \cdot x_{35} \cdot x_{24} / \left(k_{15} + x_{24}\right)\right) / k_{223}\\
\frac{dx_{60}}{dt} = \left(1 \cdot k_{167} \cdot x_{14} + 1 \cdot k_{168} \cdot x_{16} + -1 \cdot \left(k_{175} \cdot x_{60} \cdot x_{3} - k_{100} \cdot x_{13}\right) + -1 \cdot \left(k_{177} \cdot x_{60} \cdot x_{4} - k_{102} \cdot x_{14}\right) + 1 \cdot k_{188} \cdot x_{13} + 1 \cdot k_{189} \cdot x_{15} + -1 \cdot k_{208} \cdot x_{60}\right) / k_{223}\\
\frac{dx_{61}}{dt} = \left(1 \cdot \left(k_{233} \cdot x_{75} \cdot k_{224} - k_{234} \cdot x_{61} \cdot k_{223}\right) + -1 \cdot \left(k_{239} \cdot x_{2} \cdot x_{61} - k_{240} \cdot x_{63}\right) + -1 \cdot \left(k_{241} \cdot x_{61} \cdot x_{1} - k_{242} \cdot x_{64}\right)\right) / k_{223}\\
\frac{dx_{62}}{dt} = 0\\
\frac{dx_{63}}{dt} = \left(1 \cdot \left(k_{239} \cdot x_{2} \cdot x_{61} - k_{240} \cdot x_{63}\right) + -1 \cdot k_{244} \cdot x_{63}\right) / k_{223}\\
\frac{dx_{64}}{dt} = \left(1 \cdot \left(k_{241} \cdot x_{61} \cdot x_{1} - k_{242} \cdot x_{64}\right) + -1 \cdot k_{243} \cdot x_{64}\right) / k_{223}\\
\frac{dx_{65}}{dt} = 1 \cdot k_{243} \cdot x_{64} / k_{223}\\
\frac{dx_{66}}{dt} = 1 \cdot k_{244} \cdot x_{63} / k_{223}\\
\frac{dx_{67}}{dt} = \left(-1 \cdot \left(k_{227} \cdot x_{67} \cdot x_{69} - k_{228} \cdot x_{71}\right) + 1 \cdot \left(k_{237} \cdot x_{1} \cdot k_{223} - k_{238} \cdot x_{67} \cdot k_{224}\right)\right) / k_{224}\\
\frac{dx_{68}}{dt} = 0\\
\frac{dx_{69}}{dt} = \left(1 \cdot k_{225} \cdot k_{246} + -1 \cdot k_{226} \cdot x_{69} + -1 \cdot \left(k_{227} \cdot x_{67} \cdot x_{69} - k_{228} \cdot x_{71}\right) + -1 \cdot \left(k_{229} \cdot x_{69} \cdot x_{72} - k_{230} \cdot x_{73}\right)\right) / k_{224}\\
\frac{dx_{70}}{dt} = 1 \cdot k_{226} \cdot x_{69} / k_{224}\\
\frac{dx_{71}}{dt} = \left(1 \cdot \left(k_{227} \cdot x_{67} \cdot x_{69} - k_{228} \cdot x_{71}\right) + -1 \cdot \left(k_{235} \cdot x_{71} \cdot k_{224} - k_{236} \cdot x_{2} \cdot k_{223}\right)\right) / k_{224}\\
\frac{dx_{72}}{dt} = \left(-1 \cdot \left(k_{229} \cdot x_{69} \cdot x_{72} - k_{230} \cdot x_{73}\right) + -1 \cdot k_{231} \cdot x_{72}\right) / k_{224}\\
\frac{dx_{73}}{dt} = 1 \cdot \left(k_{229} \cdot x_{69} \cdot x_{72} - k_{230} \cdot x_{73}\right) / k_{224}\\
\frac{dx_{74}}{dt} = 1 \cdot k_{231} \cdot x_{72} / k_{224}\\
\frac{dx_{75}}{dt} = \left(-1 \cdot k_{232} \cdot x_{75} + -1 \cdot \left(k_{233} \cdot x_{75} \cdot k_{224} - k_{234} \cdot x_{61} \cdot k_{223}\right)\right) / k_{224}\\
\frac{dx_{76}}{dt} = 1 \cdot k_{232} \cdot x_{75} / k_{224}