[ Eq(Derivative(x1, t), 0),
  Eq(Derivative(x2, t), 0),
  Eq(Derivative(x3, t), ((-1)*k143*k112*k145*x3/(k113 + x3) + 1*k143*k114*x4/(k115 + x4))/k143),
  Eq(Derivative(x4, t), (1*k143*k112*k145*x3/(k113 + x3) + (-1)*k143*k114*x4/(k115 + x4))/k143),
  Eq(Derivative(x5, t), ((-1)*k143*k116*k146*x5/(k117 + x5) + 1*k143*k118*x6/(k119 + x6))/k143),
  Eq(Derivative(x6, t), (1*k143*k116*k146*x5/(k117 + x5) + (-1)*k143*k118*x6/(k119 + x6))/k143),
  Eq(Derivative(x7, t), ((-1)*k143*k128*k146*x7/(k129 + x7) + 1*k143*k130*x8/(k131 + x8))/k143),
  Eq(Derivative(x8, t), (1*k143*k128*k146*x7/(k129 + x7) + (-1)*k143*k130*x8/(k131 + x8))/k143),
  Eq(Derivative(x9, t), (1*k19*k110*x46 + (-1)*k143*k20*x9)/k143),
  Eq(Derivative(x10, t), ((-1)*k143*k40*k88*x20*x10/(k41*(1 + x11/k109) + x10) + 1*k143*k2*x11/(k3*(1 + x12/k5) + x11) + (-1)*(k10*k111*x10 - k11*k110*x30))/k143),
  Eq(Derivative(x11, t), (1*k143*k40*k88*x20*x10/(k41*(1 + x11/k109) + x10) + (-1)*k143*k1*k88*x20*x11/(k109*(1 + x10/k41) + x11) + (-1)*k143*k2*x11/(k3*(1 + x12/k5) + x11) + 1*k143*k4*x12/(k5*(1 + x11/k3) + x12) + (-1)*(k12*k111*x11 - k13*k110*x31))/k143),
  Eq(Derivative(x12, t), (1*k143*k1*k88*x20*x11/(k109*(1 + x10/k41) + x11) + (-1)*k143*k4*x12/(k5*(1 + x11/k3) + x12) + (-1)*(k14*k111*x12 - k15*k110*x32))/k143),
  Eq(Derivative(x13, t), (1*k143*k102*x17 + (-1)*k143*k103*x13 + (-1)*(k104*k111*x13 - k105*k110*x37))/k143),
  Eq(Derivative(x14, t), (1*k143*k59*x16 + (-1)*k143*k60*x12*x14/(k61 + x14) + (-1)*k143*k62*x25*x14/(k63 + x14) + 1*k143*k64*x15/(k65 + x15) + (-1)*k143*k66*x14 + (-1)*(k68*k111*x14 - k69*k110*x35))/k143),
  Eq(Derivative(x15, t), (1*k143*k60*x12*x14/(k61 + x14) + 1*k143*k62*x25*x14/(k63 + x14) + (-1)*k143*k64*x15/(k65 + x15) + (-1)*k143*k67*x15 + (-1)*(k70*k111*x15 - k71*k110*x36))/k143),
  Eq(Derivative(x16, t), (1*k57*k110*x47 + (-1)*k143*k58*x16)/k143),
  Eq(Derivative(x17, t), (1*k100*k110*x48 + (-1)*k143*k101*x17)/k143),
  Eq(Derivative(x18, t), ((-1)*k143*k132*k146*x18/(k133 + x18) + 1*k143*k134*x8*x19/(k135 + x19))/k143),
  Eq(Derivative(x19, t), (1*k143*k132*k146*x18/(k133 + x18) + (-1)*k143*k134*x8*x19/(k135 + x19))/k143),
  Eq(Derivative(x20, t), (1*k143*k136*x27*x21/(k137 + x21) + 1*k143*k138*x19*x21/(k139 + x21) + (-1)*k143*k140*x20/(k141 + x20))/k143),
  Eq(Derivative(x21, t), ((-1)*k143*k136*x27*x21/(k137 + x21) + (-1)*k143*k138*x19*x21/(k139 + x21) + 1*k143*k140*x20/(k141 + x20))/k143),
  Eq(Derivative(x22, t), (1*k143*k21*x9 + (-1)*k143*k22*x12*x22/(k23 + x22) + 1*k143*k24*x23/(k25 + x23) + (-1)*k143*k26*x22 + (-1)*(k28*k111*x22 - k29*k110*x38))/k143),
  Eq(Derivative(x23, t), (1*k143*k22*x12*x22/(k23 + x22) + (-1)*k143*k24*x23/(k25 + x23) + (-1)*k143*k27*x23 + (-1)*(k30*k111*x23 - k31*k110*x39))/k143),
  Eq(Derivative(x24, t), ((-1)*k143*k38*x12*x24/(k39 + x24) + 1*k143*k42*x25/(k43 + x25))/k143),
  Eq(Derivative(x25, t), (1*k143*k38*x12*x24/(k39 + x24) + (-1)*k143*k42*x25/(k43 + x25) + (-1)*(k44*k111*x25 - k45*k110*x49))/k143),
  Eq(Derivative(x26, t), ((-1)*k143*k120*k145*x26/(k121 + x26) + (-1)*k143*k122*k146*x26/(k123 + x26) + 1*k143*k124*x4*x27/(k125 + x27) + 1*k143*k126*x6*x27/(k127 + x27))/k143),
  Eq(Derivative(x27, t), (1*k143*k120*k145*x26/(k121 + x26) + 1*k143*k122*k146*x26/(k123 + x26) + (-1)*k143*k124*x4*x27/(k125 + x27) + (-1)*k143*k126*x6*x27/(k127 + x27))/k143),
  Eq(Derivative(x28, t), ((-1)*k144*k46*x49*x28/(k47 + x28) + 1*k144*k48*x29/(k49 + x29))/k144),
  Eq(Derivative(x29, t), (1*k144*k46*x49*x28/(k47 + x28) + (-1)*k144*k48*x29/(k49 + x29))/k144),
  Eq(Derivative(x30, t), (1*k144*k6*x31/(k7*(1 + x32/k9) + x31) + 1*(k10*k111*x10 - k11*k110*x30) + 1*k144*k94*x41 + (-1)*k144*(k95*x39*x30 - k96*x40) + 1*k144*k85*x44 + (-1)*k144*(k86*x38*x30 - k87*x43))/k144),
  Eq(Derivative(x31, t), ((-1)*k144*k6*x31/(k7*(1 + x32/k9) + x31) + 1*k144*k8*x32/(k9*(1 + x31/k7) + x32) + 1*(k12*k111*x11 - k13*k110*x31) + 1*k144*k91*x42 + (-1)*k144*(k92*x39*x31 - k93*x41) + 1*k144*k82*x45 + (-1)*k144*(k83*x38*x31 - k84*x44))/k144),
  Eq(Derivative(x32, t), ((-1)*k144*k8*x32/(k9*(1 + x31/k7) + x32) + 1*(k14*k111*x12 - k15*k110*x32) + (-1)*k144*(k89*x39*x32 - k90*x42) + (-1)*k144*(k80*x38*x32 - k81*x45))/k144),
  Eq(Derivative(x33, t), ((-1)*k144*k50*x32*x33/(k51 + x33) + 1*k144*k52*x34/(k53 + x34))/k144),
  Eq(Derivative(x34, t), (1*k144*k50*x32*x33/(k51 + x33) + (-1)*k144*k52*x34/(k53 + x34))/k144),
  Eq(Derivative(x35, t), (1*(k68*k111*x14 - k69*k110*x35) + (-1)*k144*k72*x32*x35/(k73 + x35) + (-1)*k144*k74*x49*x35/(k75 + x35) + 1*k144*k76*x36/(k77 + x36) + (-1)*k144*k78*x35)/k144),
  Eq(Derivative(x36, t), (1*(k70*k111*x15 - k71*k110*x36) + 1*k144*k72*x32*x35/(k73 + x35) + 1*k144*k74*x49*x35/(k75 + x35) + (-1)*k144*k76*x36/(k77 + x36) + (-1)*k144*k79*x36)/k144),
  Eq(Derivative(x37, t), (1*(k104*k111*x13 - k105*k110*x37) + (-1)*k144*k143*k106*x37/k144)/k144),
  Eq(Derivative(x38, t), (1*(k28*k111*x22 - k29*k110*x38) + (-1)*k144*k32*x32*x38/(k33 + x38) + 1*k144*k34*x39/(k35 + x39) + (-1)*k144*k36*x38 + (-1)*k144*(k80*x38*x32 - k81*x45) + 1*k144*k82*x45 + (-1)*k144*(k83*x38*x31 - k84*x44) + 1*k144*k85*x44 + (-1)*k144*(k86*x38*x30 - k87*x43))/k144),
  Eq(Derivative(x39, t), (1*(k30*k111*x23 - k31*k110*x39) + 1*k144*k32*x32*x38/(k33 + x38) + (-1)*k144*k34*x39/(k35 + x39) + (-1)*k144*k37*x39 + (-1)*k144*(k89*x39*x32 - k90*x42) + 1*k144*k91*x42 + (-1)*k144*(k92*x39*x31 - k93*x41) + 1*k144*k94*x41 + (-1)*k144*(k95*x39*x30 - k96*x40))/k144),
  Eq(Derivative(x40, t), 1*k144*(k95*x39*x30 - k96*x40)/k144),
  Eq(Derivative(x41, t), (1*k144*(k92*x39*x31 - k93*x41) + (-1)*k144*k94*x41)/k144),
  Eq(Derivative(x42, t), (1*k144*(k89*x39*x32 - k90*x42) + (-1)*k144*k91*x42)/k144),
  Eq(Derivative(x43, t), 1*k144*(k86*x38*x30 - k87*x43)/k144),
  Eq(Derivative(x44, t), (1*k144*(k83*x38*x31 - k84*x44) + (-1)*k144*k85*x44)/k144),
  Eq(Derivative(x45, t), (1*k144*(k80*x38*x32 - k81*x45) + (-1)*k144*k82*x45)/k144),
  Eq(Derivative(x46, t), (1*k144*k16*x32**k18/(k17**k18 + x32**k18) + (-1)*k19*k110*x46)/k144),
  Eq(Derivative(x47, t), (1*k144*k54*(x29*x34)**k56/(k55**k56 + (x29*x34)**k56 + (x37/k107)**k108) + (-1)*k57*k110*x47)/k144),
  Eq(Derivative(x48, t), (1*k144*k97*x36**k99/(k98**k99 + x36**k99) + (-1)*k100*k110*x48)/k144),
  Eq(Derivative(x49, t), 1*(k44*k111*x25 - k45*k110*x49)/k144) ]